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EC number: 700-903-6 | CAS number: 255830-15-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 January 1991 - 05 February 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ECC guideline - VI Amendment, Annex V, Directive 84/449/EEC
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- pentapotassium {[(hydrogen phosphonomethyl)(phosphonomethyl)-oxo-$l^{5}-azanyl]methyl}phosphonate
- EC Number:
- 700-903-6
- Cas Number:
- 255830-15-0
- Molecular formula:
- C3H7K5NO10P3
- IUPAC Name:
- pentapotassium {[(hydrogen phosphonomethyl)(phosphonomethyl)-oxo-$l^{5}-azanyl]methyl}phosphonate
- Reference substance name:
- ATMP-N-oxide-5K
- IUPAC Name:
- ATMP-N-oxide-5K
- Details on test material:
- - Name of test material (as cited in study report): Sequion CLR
- Physical state: colourless liquid
- Storage condition of test material: in a glass bottle, no specific requirements
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Italia S.p.A., Via Indipendenza, 11, 22050 - CALCO (Como)
- Age at study initiation: ca. 7-9 weeks
- Weight at study initiation: 225-250 grams (males), 200-225 grams (females)
- Fasting period before study: 16 hours (Volume of dosing was based on day 1 bodyweight. Feed was returned to rats three hours after the test article administration).
- Housing: 5 animals/sex/cage in air-conditioned rooms, in grill cages with stainless steel feeders.
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: Minimum of 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2 °C
- Humidity (%): 55 +/- 10 %
- Air changes (per hr): ca. 20 / hour
- Photoperiod (hrs dark / hrs light): 12 hours dark / 12 hours light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
Just before the treatment of the animals a weighed amount of the test article was dissolved with the suitable volume of deionized water.
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg - Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations took place at 30 minutes, 2, 4 and 6 hours on the first day after the administration and then twice a day up to the termination of the observation period. Body weights were taken once pre-trial and on days 1, 3, 8 and 14. On day 1 the animals were weighed after a 16 hour fasting.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Histological examination was not performed as no macroscopic findings emerged from necropsy. - Statistics:
- The LD50 calculation was not possible.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- dissolved
- Remarks on result:
- other: No adverse effects observed
- Mortality:
- There were no deaths.
- Clinical signs:
- Hypoactivity, shallow breathing, piloerection and hunched posture were the main clinical signs observed starting from 30 minutes and lasting up to 2 days after the test article administration. Recovery of all treated animals was achieved 3 days after treatment.
- Body weight:
- The body weight gain of all the treated animals was considered within normal limits for rats of this strain and age (except for one female rat which showed a slight decrease in body weight gain only at the day 3 weighing).
- Gross pathology:
- No changes were noted in any of the necropsied animals.
- Other findings:
- None reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- An acute oral toxicity study, conducted according to a standard acute toxicity method and in compliance with GLP, concluded an LD50 value of ≥5000 mg/kg bw/day based on no adverse effects.
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