Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-770-3 | CAS number: 25265-71-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Dipropylene glycol was found to be readily biodegradable after 28 days under aerobic conditions.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Under aerobic conditions 82% biodegradation was found in a ready biodegradability screening test, based on oxygen consumption, for 100 mg/l dipropylene glycol tested according to GLP compliant OECD Guideline 301F study (West et al., 2007). In an inherent biodegradability study (GLP compliant OECD Guideline 302A) 83.6% biodegradation was found for 18.5 mg/l dipropylene glycol (Sittingbourne Research Centre, 1994). The result of the readily biodegradability test will be used in the assessment.
In the study of West et al. (2007), 58.7 ± 1.3 % biodegradation based on O2 consumption was observed in the 10-day window, indicating that the 10-day window criterium of 60% ThOD removal for ready biodegradability was just not met. A previous study has shown that the various isomers and homologues typically comprising technical surfactant mixtures can be biodegraded preferentially and sequentially in the ready biodegradability test (Richter and Steber, 2001). In such cases, the extent of degradation occurring over the 10-d window represents the average rate of degradation for all components of the mixture and has little relevance for individual components. For this reason, a recent revision to Section 3: Degradation and Accumulation of the OECD guidelines has excluded the 10-d window criterion for ready biodegradability tests involving substances that occur as mixtures of isomers and/or homologues in their purest commercial form (OECD, 2006). In the present study, markedly different rates of biodegradation were observed among the discrete propylene glycol oligomers having one to four oxypropylene repeating units. Kawai (1987) also showed that biodegradation of dipropylene glycol involves preferential oxidation of the structural isomers having secondary alcohol groups. Thus, different rates of biodegradation could be expected for the distinct homologues and isomers comprising the propylene glycol substances, and the 10-d window criterion should not be applied in evaluating their ready biodegradability.
It is therefore concluded that dipropylene glycol can be regarded as ready biodegradable.
Significant biodegradation (>20%) was found in a screening test with natural seawater after 64 days (West et al., 2007).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.