Registration Dossier
Registration Dossier
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EC number: 203-956-9 | CAS number: 112-30-1
Carcinogenicity
Administrative data
Description of key information
There are no reliable carcinogenicity studies on decan-1-ol (CAS 112-30-1).
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Species:
- mouse
- Quality of whole database:
- Rel 4 study
Justification for classification or non-classification
Based on the weight of evidence available, decan-1-ol (CAS 112-30-1) is not classified as carcinogenic under Regulation 1272/2008 (CLP)
Additional information
In a carcinogenicity study by Sice (1966; rel 4), the tumour promoting activity of a range of alcohols, including decan-1-ol was investigated in mice. Tumour promoting activity was observed in some of the alcohols; the maximum effect being observed at C10 (decanol). It was also noted however that skin irritation was present at the application site in all of these skin painting experiments; the most severe irritation being observed with the C10 and C12 alcohols. Unfortunately this is a significant confounder in skin painting studies and the role of sustained irritation in tumour development of non-genotoxic chemicals has been well established. it is therefore considered likely that the tumour effects noted were due to the irritation observed in the study.
Although Column 2 of REACH Annex X requires a carcinogenicity study (required in Section 8.9.1) if the substance has a wide dispersive use, the weight of evidence across the category suggests that decan-1-ol is not carcinogenic. This is based on a large set of various types of repeated dose studies across the category which do not offer any evidence of treatment-related induction of hyperplasia / pre-neoplastic lesions for decan-1-ol or structurally related alcohols (though reporting is limited in many cases). In addition, decan-1-ol does not have any genotoxic effects and it is a naturally-occurring substance.
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