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Diss Factsheets
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EC number: 225-716-2 | CAS number: 5026-74-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
It is known from similar substances that the glycidyl ether substituents are determining the toxicity profile of the substance. It is considered that genotoxicity and skin sensitization and irritation are due to the glycidyl ether substituent. Glycidyl ethers are rapidly cleaved by hydrolysis by epoxyde hydrolases present in the skin, in the liver and in most tissues. Epoxyde hydrolases are therefore a very efficient mechanism of detoxification.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The available toxicity data show that the substance as described in section 1 is bioavailable. No data on the absorption rate is available. The substance is not lipophilic and therefore there is a very low bioaccumulation potential. The substituent determining toxicity are likely the glycidyl ethers because they can bind to DNA and/or protein. Following absorption the glycidyl ether functions of the substance are considered to be rapidly hydrolysed and the substance detoxified. At high doses this metabolic pathway may be overloaded resulting in the presence of the unmetabolised substance in circulation. It is considered that the hydrolysed substance is either further metabolised or excreted by the kidneys.
Bioavailability is defined as the proportion of a drug or other substance which enters the circulation when introduced into the body and so has the ability to have an active effect. It is well documented within literature that LogKow, molecular weight and molecular flexibility, measured by number of rotatable bonds, low polar surface area or total hydrogen bond count are all important predictors of oral bioavailability (Veber et al. (2002)). Based on these principles it can be concluded that the bioavailability of p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline and m-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline will be comparable. It should however, be noted that for p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline the LogKow is fractionally lower and subsequently this leads to improved aqueous solubility. This increased solubility may result in better gastrointestinal dispersion thereby toxicological endpoints for this isomer may be more conservative than those determined with the m-isomer.
Further supporting the hypothesis that bioavailabilty will be slightly improved and that data generated with the p-isomer will be conservative e.g. protective of the m-isomer is the difference in hydrolysis whereby at all pHs the DT50 of the p-isomer was ca. 2 days compared to 5 days for the m-isomer. It should also be noted that following oral gavage hydrolysis and production of transformation products will be fastest under the acid conditions of the stomach. This is concluded based on the positive correlation between increasing pH and increasing DT50. Any untransformed parent material that passes from the acid condition into the neutral pH duodenum/intestine could therefore lead to some target organ toxicity as the rate of transformation is likely to reduce with pH and residence time increase due to the slower transit times that occur in the duodenum (ca. 25 mins in stomach and 30 to >120 mins depending on which quarter of the duodenum/intestine that site of contact is occurring Purdon and Bass (1973).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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