Registration Dossier
Registration Dossier
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EC number: 231-298-2 | CAS number: 7487-88-9
Endpoint summary
Administrative data
Description of key information
No studies with magnesium sulphate are available. Based on reliable studies with potassium sulphate showing no to minimal irritation to the skin and eye, it is concluded that that magnesium sulphate is not irritating to skin and eye. Results with ammonium sulphate are in agreement with this.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
For both the skin and eye irritation no studies for magnesium sulphate are available. In the category of inorganic sulphates, well performed study (reports) are present for a.o. potassium sulphate. For skin irritation an in vitro test with human skin according to EU guideline B46 and draft OECD guidelines with potassium sulphate the soluble grade (incl. 15% KHSO4) shows no irritation. This is considered to be the worst case form compared to the potassium sulphate solid form (and thus also the magnesium sulphate). An in vivo eye irritation study in rabbits performed according to OECD 405 shows that potassium sulphate (solid) is not irritating. Although some irritation was observed in the first 24 hours, this was in most animals reversible within 48 hours. Two animals showed some redness (score 1) up to 7 days after exposure, but reversible within 14 days. As magnesium sulphate does not contain KHSO4, this study can be used for magensium sulphate. In addition skin and eye irritation studies with ammonium sulphate also show no irritation. Therefore, magnesium sulphate is considered to be not irritant to skin and eyes.
Justification for classification or non-classification
Based on the available data magnesium sulphate does not have to be classified for skin or eye irritation according to Directive 67/548/EC and to the CLP Directive.
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