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Diss Factsheets
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EC number: 201-607-5 | CAS number: 85-44-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Gross or histopathological examination was not performed, big volumes of DMSO was used as a solvent
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- Ten male rats/dose (bw: ca. 160-180 g), single oral application by gavage, substance dissolved in DMSO (2 ml/100 g bw), observation time: 14 d, calculation of LD50 according to Fink (1965) Arzneim.-Forsch. 15, 624
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Phthalic anhydride
- EC Number:
- 201-607-5
- EC Name:
- Phthalic anhydride
- Cas Number:
- 85-44-9
- Molecular formula:
- C8H4O3
- IUPAC Name:
- 1,3-dihydro-2-benzofuran-1,3-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- male Wistar-II-rats, SPF, weight 160 - 180 gr, husbandry: 5 animals per cage
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Details on oral exposure:
- no further data
- Doses:
- 100, 500, 1000, 2000, 3100, 5000 mg/kg bw in DMSO
- No. of animals per sex per dose:
- 10 males per dose
- Control animals:
- not specified
- Details on study design:
- No further data
- Statistics:
- According Fink and Hund, Arzneimittelforsch. (1965), 15, 624
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 530 mg/kg bw
- Mortality:
- Dose 100 mg/kg, mortality 0/10; dose 500 mg/kg, mortality 2/10; dose 1000 mg/kg, mortality 2/10, dose 2000 mg/kg, mortality 4/10; dose 3100 mg/kg, mortality 9/10; dose 5000 mg/kg, mortality 10/10
- Clinical signs:
- other: Sedation, disturbances of equilibrium
- Gross pathology:
- no data
- Other findings:
- See: Any other information on results including tables
Any other information on results incl. tables
Dose-group, time of death, No of rats which died, No of rats with
symptoms:
100 mg/kg bw, no deaths, 0/10, 0/10
500 mg/kg bw, 3-4 d, 2/10, 10/10
1000 mg/kg bw, 3 d, 2/10, 10/10
2000 mg/kg bw, 2-3 d, 4/10, 10/10
3100 mg/kg bw, 2-3 d, 9/10, 10/10
5000 mg/kg bw, 2 d, 10/10, 10/10
Symptoms: sedation, imbalance, and bloody eyes.
No gross or histopathological examination.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
Method: single orale application per gavage of test substance (dose 100, 500, 1000, 2000, 3100, 5000 to 10 male rats, post-observation time 14 days)
Result: LD50 = 1530 mg/kg bw (male rats)
Reference: Loeser (Bayer AG), 1978
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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