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Diss Factsheets
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EC number: 639-566-4 | CAS number: 165184-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test was conducted similarly to OECD test guideline No. 402 with minor deviations: occlusive dressing, number of animal tested is not standard, no details on test animals and conditions, no data on gross pathology.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- occlusive dressing, number of animal tested is not standard, no details on test animals and conditions, no data on gross pathology
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Details on test material:
- - Name of test material (as cited in study report): CFI-A alpha-Hexyl Cinnamate Aldehyde
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing: in cages
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 12 cm wide and covering the entire circumference of the rabbits
- % coverage:
- Type of wrap if used: rubber sheeting and the ends taped to the rabbits
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no details given
- Time after start of exposure: 24 h - Duration of exposure:
- The animals were exposed during 24 h
- Doses:
- One animal was treated at 1000 mg/kg bw, one animal at 2000 mg/kg bw level and three animals were treated at 3000 mg/kg bw
- No. of animals per sex per dose:
- A total of 5 female albino rabbits were treated.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: after 24h of tretament, the rubber sheets were removed and the animals were observed during 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- Other examinations performed: only observation was done
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Remarks on result:
- other: no animals died at this dose
- Mortality:
- No animals died
Any other information on results incl. tables
Moderate erythema was seen with all compounds. Occassional sloughing was seen but this was in large part due to damage caused by the removal of the tape from the skin and is not believed to be drug related. All rabbits appeared normal by the end of the test period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dermal LD50Combined > 3000 mg/kg bw
- Executive summary:
In an acute dermal toxicity study female albino rabbits were exposed to undiluted Hexyl cinnamic aldehyde (HCA) for 24 hours (area exposure of 12 cm) at doses of 1000 (1 animal), 2000 (1 animal) or 3000 (3 animals) mg/kg bw under an occlusive coverage. Animals then were observed for 7 days.
Dermal LD50 Combined > 3000 mg/kg bw
No animals died at any dose level tested. Moderate erythema was seen with all compounds. All rabbits appeared normal by the end of the test period
Under the test conditions, HCA is not classified according to the Directive 67/548/EEC and Regulation (EC) No. 1272/2008.
This study is considered as acceptable and satisfies the guideline requirement for an acute dermal toxicity study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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