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EC number: 247-304-1 | CAS number: 25869-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation (OECD 404): not irritating
Eye irritation (OECD 405): not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/ corrosion:
A possible skin irritation effect of ammonium iron(3+) hexakis(cyano-C) ferrate(4-) was investigated in a study performed according to OECD 404 and GLP (Zelenák, 2011). The powdery test substance was applied by an occlusive patch on the shaved skin of 3 male New Zealand White rabbits for 4 h. After patch removal, the treated skin was cleaned with water.
Edema and erythema formation were assessed 1, 24, 48 and 72 h after removal of the test substance using the Draize scoring system. Very slight erythema and edema formation was observed in one animal at 1 and 24 h post application. The skin reaction was reversible within 48 h. No erythema and/or edema formation was noted in another animal during the observation period. In conclusion, under the test conditions, the test substance was not irritating to the skin.
A second skin irritation study with the submission substance (Iron Blue) is available, performed prior to the invention of GLP and adoption of the guideline but according to the standards at the time and with acceptable deviations from guideline protocols, which serves as supporting study (Cuthbert and McGregor, 1977); the test substance was compared with a standard irritant, 10% aqueous sodium lauryl sulphate. The shaved dorsal skin of New Zealand white rabbits was exposed to 0.5 mL of the test material as a paste in water (30% w/w) for 24 hours under occlusive conditions. After exposure the skin was cleaned from the residual test substance. Skin reactions were assessed according to the Draize scoring system 24 and 72 h after removal of the test substance. Very slight erythema and edema was observed at the reading time point 24 h. Both effects had completely revealed within 72 h.
Eye Irritation:
The eye irritation potential of ammonium iron(3+) hexakis(cyano-C) ferrate(4-) was tested in accordance with OECD 405 and GLP (Tavaszi, 2011b). The powdery test substance was instilled into the left eye of each of three male New Zealand White rabbits. The other eye was not treated and served as control. At the first reading time point 1 h after instillation, the residual test substance was rinsed with physiological saline solution. The grades of ocular reaction (conjunctivae redness, conjunctivae chemosis, cornea, iris) were assessed 1, 24, 48 and 72 h after instillation of the test substance.
Very slight conjunctivae redness (score 1) was noted in all animals 1 h after instillation of the test substance. At the 24 h reading time point, very slight conjunctivae redness (score 1) was still observed in 2/3 animals. The effect was reversible in all animals within 48 h. At the 1 h reading time point, very slight chemosis (score 1) was observed in 1/3 animals and very slight corneal opacity (score 1) was noted in 2/3 animals. Both effects were reversible within 24 h. No effect on the iris of any animal was observed at any time point. In conclusion, under the test conditions, the test substance was not irritating to the eyes.
There is a second eye irritation study available for the submission substance (Iron Blue), performed prior to the invention of GLP and adoption of the guideline, but according to the standards at the time and with acceptable deviations from guideline protocols, which serves as supporting study (Cuthbert and McGregor, 1977). A single sample of 50 mg of the test substance was instilled into one eye of three male and three female Albino rabbits. Observations were made 24, 48, 72 hours and 7 days after instillation. Eye reactions were assessed according to the Draize scoring system. The test substance was concluded not to be an eye irritant.
Justification for selection of skin irritation / corrosion endpoint:
There are two studies available for ammonium iron(3+) hexakis(cyano-C) ferrate(4-). The selected study is the most adequate and reliable study based on overall assessment of quality.
Justification for selection of eye irritation endpoint:
There are two studies available for ammonium iron(3+) hexakis(cyano-C) ferrate(4-). The selected study is the most adequate and reliable study based on overall assessment of quality.
Justification for classification or non-classification
The available data on skin and eye irritation of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
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