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EC number: 245-205-8 | CAS number: 22766-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Since no studies investigating the long-term toxicity of
2-octyldodecyl myristate (CAS 22766-83-2) to aquatic invertebrates are
available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a
read-across to the structurally related source substances 2-octyldodecyl
isooctadecanoate (CAS 93803-87-3) and Fatty acids, C8-10, C12-18-alkyl
esters (CAS 95912-86-0) was conducted. The source substances are
representative to evaluate the long-term toxicity of the target
substance to aquatic invertebrates. The target substance is
characterised as an ester of C18 iso branched fatty acid esterified with
2-octyldodecan-1-ol. The two source substances are structurally very
similar to the target substance. 2-octyldodecyl isooctadecanoate (CAS
93803-87-3)is characterised by a longer fatty acid chain length (C18 iso
branched) and by the same alcohol component (2-octyldodecan-1-ol)
whereas Fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) is a
UVCB substance consisting of mainly C8-C10 fatty acids esterified with
C12-C18 alcohol. The substance is smaller based on its molecular weight
and thus expected to exhibit a higher solubility in water and represents
a worst case since bioavailability is increased. This read-across is
justified in detail in the overall summary (IUCLID Section 6.1) and
within the analogue justification in IUCLID Section 13. In this case of
read-across, the best suited (highest degree of structural similarity,
nearest physico-chemical properties) read-across substance was used for
the assessment.
No experimental studies investigating the long-term toxicity with the
source substance 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) to
aquatic invertebrates are available. A statement from a laboratory is
available indicating that the study is technically not feasible due to
substance characteristics (Bogers, 1998). Acute testing in Daphnia magna
was performed by exposing organisms to Water Accommodated Fractions
(WAFs). However, it is not common practice to use this approach in a
prolonged toxicity test. The use of a column generator with the test
substance coated on an inert carrier (glass beads or celite) is not
possible as the test substance is a liquid. The testing in a
flow-through system is also no possible alternative, since the
hydrophobic character of the test substance hampers any way of mixing
with the dilution water. Based on the high hydrophobicity, there is no
analytical method sensitive enough to detect concentrations of the test
substance in water samples. As a result, it is not possible to give any
analytical support to the reproduction test with Daphnia magna. This
analytical support is essential to meet the acceptability criterion for
evidence that the actual concentration had been maintained within a 20%
window during the total test period. Owing to the fact that the test
substance is a liquid with water solubility below detection limit (<
0.05 mg/L) and a log Kow of > 7, it is not possible to prepare solutions
that can be tested in a 21 d reproduction test with Daphnia magna.
Further, these characteristics support the expectation that it will not
be very likely that bioavailable concentrations of the test substance
will ever occur in the water phase, i.e. concentrations high enough to
induce any acute or chronic effects in aquatic organisms. Thus, no
chronic test with aquatic invertebrates was conducted.
The study with the second source substance fatty acids, C8-10,
C12-18-alkyl esters (CAS 95912-86-0) was performed according to OECD 211
(GLP) (Salinas, 2013). Daphnia magna was exposed to a nominal loading
rate of 10 mg/L (Water Accommodated Fraction). Chemical analysis of the
test substance concentrations was not possible since no suitable
analytical method could be developed to detect the test substance. No
effects on reproduction of D. magna were observed up to the water
solubility limit (< 0.05 mg/L) resulting in a NOELR (21 d) ≥ 10 mg/L.
Based on the available results from structurally related read-across
substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5)
which are characterised by a similar ecotoxicological profile and
comparable structure, it can be concluded that 2-octyldodecyl myristate
will not exhibit long-term effects to aquatic invertebrates up to the
limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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