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EC number: 287-494-3 | CAS number: 85536-14-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976-04 to 1977-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented, equivalent to guideline
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
Test material
- Reference substance name:
- Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts
- EC Number:
- 270-115-0
- EC Name:
- Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts
- Cas Number:
- 68411-30-3
- Molecular formula:
- Not applicable for UVCB
- IUPAC Name:
- sodium 4-undecylbenzenesulfonate
- Details on test material:
- - Name of test material: C11.8 LAS; Linear Alkylbenzene Sulfonate; (TSIN = APS-71.031)
- Substance type: Pure active substance
- Physical state: N/A
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: all concentrations
- Sampling method: Samples were taken from test vessels on day 0, and every 3-5 days through out the 21-day test.
- Sample storage conditions before analysis: Preserved with 1% formaldehyde and stored at 5 C until analysis.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Direct dilution of the appropriate amount of test substance into blended well water
- Controls: Blended well water
- Evidence of undissolved material: no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain/clone: N/A
- Source: In-house culture
- Age of parental stock: not specified
- Age of test organisms: <12 h old at beginning of test
- Feeding during test: yes
- Food type: ground trout chow/alfalfa mixture, 1000 mg/L
- Amount: 5 mg/L
- Frequency: Each diluter cycle
ACCLIMATION
- Acclimation period: Not specified
- Acclimation conditions (same as test or not): N/A
- Type and amount of food: N/A
- Feeding frequency: N/A
- Health during acclimation (any mortality observed): N/A
METHOD FOR PREPARATION AND COLLECTION OF EARLY INSTARS OR OTHER LIFE STAGES: Young were manually siphoned from existing culture units.
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
Test conditions
- Hardness:
- 120 +/- 18 mg/L CaCO3
- Test temperature:
- 21 +/- 1 C
- pH:
- 7.5 +/- 0.2 SU
- Dissolved oxygen:
- 8.9 +/- 0.4 mg/L
- Salinity:
- N/A
- Nominal and measured concentrations:
- The nominal test concentrations were not specified in the study report. Mean Measured concentrations were 0, 0.32, 0.59, 1.18, 2.52, and 4.85 mg/L C11.8 LAS (active ingredient).
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Material: 1 liter glass beakers, 1 L test solution
- Aeration: N/A (test was flow-thru)
- Type of flow-through: Mount and Brungs proportional diluter, with modifications
- Renewal rate of test solution: 125 ml per 20 min cycle, or one chamber volume every 2.5 hr.
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 5 daphnids/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Blended well water (a mixture of well water and deionized water)
- Total organic carbon: N/A
- Particulate matter: N/A
- Metals: N/A
- Pesticides: N/A
- Chlorine: N/A
- Alkalinity: N/A
- Ca/mg ratio: N/A
- Conductivity: N/A
- Salinity: N/A
- Culture medium different from test medium: No
- Intervals of water quality measurement: Daily
OTHER TEST CONDITIONS
- Adjustment of pH: N/A
- Photoperiod: N/A
- Light intensity: N/A
EFFECT PARAMETERS MEASURED: Mortality, 24 hr, 96 hr, 7 days, then daily to end of test. Reproduction, daily beginning day 7 or 8 to end of test.
RANGE-FINDING STUDY: no - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.18 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Parent (F0) Survival and reproduction (Total # young in 21 days; and Mean Brood Size)
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 1.5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Total young production
- Remarks on result:
- other: 95% CL 0.75-3.33 mg/L
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- 1.67 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CL 1.28-2.18 mg/L
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 2.3 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Average brood size
- Remarks on result:
- other: 95% CL 1.62-3.55 mg/L
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 2.31 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: Percentage of days reproduction occurred
- Remarks on result:
- other: 95% CL 0.30-4.18 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3.94 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CL 2.87-6.83 mg/L
- Details on results:
- - Mortality of parent animals: Controls, 10%
- No. of offspring produced per Control: 39
- Body length and weight of parent animals: N/A
- Type and number of morphological abnormalities: N/A
- Type and number of behavioural abnormalities: N/A
- Number of males and females (parental): N/A
- Time to first brood release or time to hatch- 7 or 8 days
- Egg development time: N/A
- Brood size: Control, 8.0 (mean)
- Time to sexual maturity: N/A
- Type and magnitude of biochemical changes: N/A
- Other biological observations: N/A
- Effect concentrations exceeding solubility of substance in test medium: no - Reported statistics and error estimates:
- All results were calculated with a computerized probit analysis program after Finney (1964, 1971). Survival data for 96 hr and 21 days was used to calculate LC50 values and confidence limits. All results were calculated based on mean measured concentrations of test material.
Any other information on results incl. tables
Chronic Toxicity of C11.8 LAS to Daphnia magna (study # 20710)
Mean Measured Test Conc (mg/L) |
% Survival |
Total Young Produced |
Mean Brood Size |
% of Days that Reproduction Occurred |
0 |
90 |
786 |
8.0 |
82 |
0.32 |
85 |
1445 |
11.7 |
96 |
0.59 |
85 |
1131 |
9.7 |
90 |
1.18 |
75 |
1036 |
10.7 |
86 |
2.52 |
40 |
477 |
7.9 |
71 |
4.85 |
0 |
0 |
0 |
0 |
N=20 organisms at beginning of test (4 replicates of 5 organisms each).
LAS = linear alkylbenzene sulfonate.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 21 day NOEC of C11.8 LAS to Daphnia magna was 1.18 mg/L, based on survival and reproduction. The 21 day LC50 was 1.67 mg/L. Results are based on the mean measured concentration of the active ingredient.
- Executive summary:
The long-term toxicity of C11.8 LAS (linear alkylbenzene sulfonate)) was evaluated in a 21 day survival and reproduction test with Daphnia magna, following the OECD 211 guideline. Four replicates per concentration, 5 organisms per replicate, were tested in a flow-through system (a modified Mount and Brungs proportional diluter). Mean measured concentrations were: Control, 0.32, 0.59, 1.18, 2.52, and 4.85 mg/L active ingredient (C11.8 LAS).
Survival was monitored at 24 hr, 96 hr, 7 days and daily thereafter. Reproduction was monitored beginning with the production of the first brood on day 7 or 8, and daily thereafter. LC50s and EC50s were calculated by probit analysis. Results are based on the mean measured concentration of the active ingredient.
The 21-day NOEC was 1.18 mg/L, based on both survival and reproduction. The 21-day LC50 was 1.67 mg/L (95% CL 1.28 -2.18 mg/L). The 21-day EC50s, based on total young production, average brood size, and % days reproduction occurred, were 1.50, 2.30, and 2.31 mg/L, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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