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EC number: 204-506-4 | CAS number: 121-91-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No studies are available on the short-term toxicity of the free acid form of isophthalic acid to freshwater invertebrates, however a reliable (Klimisch 1, guideline- and GLP- compliant) study addresses the short-term toxicity of its structural analogue terephthalic acid.
In this study (Government of Japan, Ministry of the Environment, 2003b), Daphnia magna were exposed to high purity TPA (free acid), dosed from a stock solution prepared with DMSO, at a concentration intended to approximate to TPA's aqueous solubility limit (ca. 17 mg/L at 25 degrees C):
D. magna 48 -h EC50 (semi-static): >20.1 mg TPA/L, 96 -h NOEC: 20.1 mg TPA/L.
This endpoint is a mean measured value and represents the maximum limit concentration achievable under the test conditions. It demonstrates an absence of toxicity at concentrations up to the solubility limit of TPA in water. Based on read-across, the same is considered to apply to IPA, at the corresponding, higher solubility limit of ca. 120 mg/L at 25 degrees C.
Support for this proposition is provided by another study (Knacker et al., 1993b, Klimisch 1) in which D. magna were exposed to IPA following conversion to its sodium salt(s). Daphnia were exposed to IPA following its treatment with NaOH solution, and exposure in this study was consequently to sodium isophthalate. No toxicity was observed under these conditions:
D. magna 48 -h EC50 (static): >952 mg IPA-equiv/L, 96 -h NOEC: 952 mg IPA-equiv/L.
These endpoints are mean measured values that represent the highest concentration applied and demonstrate the low intrinsic toxicity of the isophthalate moiety.
Isophthalic acid and its more environmentally relevant isophthalate sodium salt exhibit very low short-term toxicity to freshwater invertebrates.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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