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EC number: 208-167-3 | CAS number: 513-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP-compliant guideline study with the following deviations: - According to the guideline, healthy young adults should be used. The age of the rats was missing in this report. - The analytical purity of the test substance is not indicated in the report.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- (Adopted: 12 May 1981)
- Deviations:
- yes
- Remarks:
- (see rational for reliability)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Barium carbonate
- EC Number:
- 208-167-3
- EC Name:
- Barium carbonate
- Cas Number:
- 513-77-9
- Molecular formula:
- BaCO3
- IUPAC Name:
- barium carbonate
- Test material form:
- solid
- Details on test material:
- No further details available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. A. Ivanovas, 7964 Kisslegg/Allgäu
- Age at study initiation: Not reported
- Weight at study initiation: Males: 100-125 g; Females: 100-115 g
- Housing: Group housing of five animals per sex per cage in labelled Makrolon cages (type III) containing sawdust bedding material (Fa. Brandenburg, 2849 Goldenstedt-Arkeburg).
- Diet (ad libitum except overnight prior to and approx. 4 hours after dosing): Pelleted rodent diet (Ssniff R10 pellets, Ssniff Versuchstierdiäten, 4770 Soest/Westf.
- Water (ad libitum): Tap water
- Acclimation period: 5 days before start of treatment
ENVIRONMENTAL CONDITIONS
Animals were housed in a controlled environment.
- Temperature: ca. 20°C
- Relative humidity: 40 - 60 %
- Air changes: Approx. 10 air changes per hour
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1%
- pH value of suspensions: 10
MAXIMUM DOSE VOLUME APPLIED: 5.0 ml/kg
The control animals received the vehicle alone. - Doses:
- 1470 mg/kg, 1780 mg/kg, 2150 mg/kg
- No. of animals per sex per dose:
- 5 male / 5 female
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: On the day of dosing animals were observed for signs of reaction to treatment at frequent intervals. On subsequent days animals were observed at leaste once daily. Individual bodyweights were recorded on the day of dosing and on days 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- The acute oral median lethal dose (LD50) based on the mortality rate (x/n) during 14 days after dosing was calculated using the method of Finney (1971), Probit Analysis (3rd Edition) Cambridge University Press.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 690 mg/kg bw
- 95% CL:
- 1 060 - 2 010
- Mortality:
- Mortalities occured within 72 hours after dosing.
Number of dead males per dose:
Control: 0/5
1470 mg/kg: 2/5
1780 mg/kg: 4/5
2150 mg/kg: 4/5
Number of dead females per dose:
Control: 0/5
1470 mg/kg: 1/5
1780 mg/kg: 2/5
2150 mg/kg: 4/5 - Clinical signs:
- other: Slight pilo-erection was observed in the control animals on the day of dosing. Clinical signs observed on the day of dosing in rats treated with bariumcarbonate included pilo-erection, hunched posture, pallor of extremities, abnormal gait (waddling), incr
- Gross pathology:
- Autopsy mainly revealed congestion of liver and and inflammation of the glandular region of the stomach in rats that died during the study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the results of this study, an LD50 of 1690 mg/kg bw has been calculated for males and females for BaCO3.
- Executive summary:
In a GLP compliant acute oral toxicity study, performed according to OECD guideline 401, the test item BaCO3 was administered to groups of 5 male and 5 female Sprague Dawley rats at dose levels of 1470, 1780 and 2150 mg/kg body weight.
Mortalities occurred within 72 hours after dosing. Signs of reaction to treatment included pilo-erection, hunched posture, pallor of extremities, abnormal gait (waddling), increased or decreased respiratory rate, laboured respiration, diarrhoea, chromodakryorrhoea, decreased motility and loss of righting reflex. Complete recovery was evident in surviving animals by day 3 as judged by external appearance and behaviour.
Autopsy mainly revealed congestion of liver and inflammation of the glandular region of the stomach in rats that died during the study.
Body weight gain was poor in the surviving male rat of the highest dose group (2150 mg/kg) and one female rat of the mid-dose group (1780 mg/kg).
In conclusion, the LD50 of BaCO3 is calculated to be 1690 mg/kg body weight by oral route in the rat.
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