Registration Dossier
Registration Dossier
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EC number: 203-090-1 | CAS number: 103-23-1
Endpoint summary
Administrative data
Description of key information
WoE: not sensitizing
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitizing properties of the structure of Di-(2-ethylhexyl)adipate were considered by expert judgement, and indications for an alert were considered not present. This was confirmed by using a validated quantitative structure-activity relationship (QSAR), OASIS-LMC, that predicted both the parent compound and its metabolites as non-sensitiser. Additionally, the available animal studies, a patch test with rabbits and a Draize test with guinea pigs, did not indicate a skin sensitising effect of DEHA (Mallette 1952; CFTA,1967).
Justification for classification or non-classification
Based on the available data, DEHA is considered to be not sensitising. In accordance with Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, classification is not necessary for sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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