Registration Dossier
Registration Dossier
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EC number: 201-185-2 | CAS number: 79-20-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Study similar to OECD 401. Deviation: only male rats used. Full data is not available for method and individual animal weight clinical effects because it is a publication. Non -GLP
- GLP compliance:
- no
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Methyl acetate
- EC Number:
- 201-185-2
- EC Name:
- Methyl acetate
- Cas Number:
- 79-20-9
- Molecular formula:
- C3H6O2
- IUPAC Name:
- methyl acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 4 - 5 weeks old, 90-120 grams in weight. Reared in private colony fed Rockland rat diet.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Dosages were arranged in a logarithmic series differing by a factor of two
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Statistics:
- Estimated by the method of Thomson using the Tables of Weil.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 482 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 = 6482 mg/kg bw (rat).
- Executive summary:
LD50 = 6482 mg/kg bw (rat).
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