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Diss Factsheets
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EC number: 235-819-4 | CAS number: 12777-87-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 December 2009 - 17 February 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study generated according to internationally accepted testing guidelines.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EC 440/2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sulphuric acid, compound with graphite
- EC Number:
- 235-819-4
- EC Name:
- Sulphuric acid, compound with graphite
- Cas Number:
- 12777-87-6
- Molecular formula:
- Cm+ HSO4-* n H2SO4
- IUPAC Name:
- sulphuric acid, compound with graphite
- Details on test material:
- Expandable Natural Graphite
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: WISTAR Crl: WI(Han) rats (full barrier)
- Details on test animals or test system and environmental conditions:
- Body weight of test animals at the beginning of the study: females: 205 - 233 g, males: 251 - 286 gThe animals were derived from a controlled full barrier maintained breeding system (SFP).The animals were barrier maintained (Full-barrier) in an air conditioned room-Temperature: 22 +/- 3 °C- Rel. humidity: 55 +/- 10 %- Artificial light, sequence being 12 hours light, 12 hours dark- Air change: 10 x / hour- Free access to Altromin 1324 maintenance diet for rats and mice- Free access to tap water, sulphur acidified to a pH value of approx. 2.8 (drinking water, municipal residue control, microbiol. controlled periodically)- The animals were kept individiually in IVC cages, type III H, polysulphone cages on Altromin sawfiber bedding- Certificates of food, water and bedding are filed at BSL Bioservice- Adequate acclimatisation period (at least 5 days)
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipping
- Vehicle:
- other: Aqua ad injectionem (B. Braun melsungen, lot no. 7494A191)
- Controls:
- no
- Amount / concentration applied:
- The test item was applied as a single dose, uniformly over an area which was approx. 10% of the total body surface. The test item was held in contact with the skin by a dressing throughout a 24-hour period. The dressing consisted of a gauze-dressing and non-irritating tape and was fixed with an additional dressing in a suitable manner.At the end of the exposure, residual test item was removed by using tap water.
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- Animals were observed for 14 days after dosing.
- Number of animals:
- 10 (5 female and 5 male animals were used)
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Remarks:
- male rat
- Time point:
- other: during entire observation period
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: the observation period
- Irritant / corrosive response data:
- Signs of erythema was assessed on one female rat during entire observation period.
- Other effects:
- A small wound close to the application site was observed (day 2 - day 12) on the animal which showed erythemal effects. A further male rat showed slight bloody secretion at the penis on day 2 of the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
In an acute dermal toxicity test with Expandable Natural Graphite minor skin changes at the application sites of only one test animal was observed throughout the observation period. Despite this observation it can be stated that the substance is primary not a skin irritant.
In an acute dermal toxicity test with Expandable Natural Graphite no observations regarding skin corrosive effects have been conducted.
In addition, documented occupational experience with the handling and use of sulphuric acid, compound with graphite has revealed only minor dermal irritation (i.e. irreversible damage to the skin) in one case but no dermal corrosion during up to 20 years of manufacture, handling and use.
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