Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-902-6 | CAS number: 75-79-6
Endpoint summary
Administrative data
Description of key information
A 3-minute application of the test material undiluted to occluded rabbit skin resulted in moderate edema and full thickness necrosis on the test animals within one hour after contact (BRRC 1989). Similarly, instillation of the smallest volume of the test material into the eye resulted in severe eye injury (BRRC 1981). The selected key studies were conducted according to test protocols which are comparable to today's guideline requirements, however they were not compliant with GLP.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The most recent and reliable studies were selected as key. The skin irritation, reliability 2 supporting study (BRRC 1981) reported necrosis of the test site and both this and the secondary source (IUCLID 2000) were in agreement that the test material is corrosive. For eye irritation, only a key study is included.
Trichloro(methyl)silane is rapidly hydrolysed to methylsilanetriol and hydrogen chloride in the presence of moisture. Therefore signs of skin and eye irritation/corrosion are due to the hydrolysis product HCl.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
The available data indicate that the substance should be classified Corrosive; 'R35 Causes severe burns' under Directive 67/548/EEC and 'Skin Corr. 1A' under Regulation 1272/2008. This is based on the skin irritation/corrosion data that show the test substance to be clearly corrosive to the skin. It is assumed that substances that are corrosive to the skin are also damaging to the eyes, so there is no separate labelling for the eyes. There are no specific data for respiratory irritation. However, the pathology examination in the key acute inhalation study revealed signs of respiratory irritation/corrosion. The test substance is labelled as 'R37 Irritating to respiratory system', and the hazard statement 'EUH071 Corrosive to the respiratory tract' is proposed.
The current entry in Annex I of Directive 67/548/EEC includes classification as Irritant Xi; R36/37/38. However, the available data indicate that this classification is not sufficient.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
