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EC number: 701-417-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- transformation / dissolution of metals and inorganic metal compounds
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-08-23 to 2012-02-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- deviations do not effect the validity of the study
- Qualifier:
- according to guideline
- Guideline:
- OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
- Version / remarks:
- (ENV/JM/MONO(2001)9): Guidance Document on Transformation / Dissolution of Metals and Metal Compounds in Aqueous Media
- Deviations:
- yes
- Remarks:
- please refer to the field " Principles of method if other than guideline"
- Qualifier:
- according to guideline
- Guideline:
- other: EEC guideline SANCO/3029/99 rev. 4 dated 11/07/00: Working document “Guidance for generating and reporting methods of analysis in support of residue data requirements for Annex II (part A, Section 4) and Annex III (part A, Section 5)
- Deviations:
- yes
- Remarks:
- please refer to the field " Principles of method if other than guideline"
- Principles of method if other than guideline:
- - As per sponsor request, the 7d-full test was performed with two aqueous solutions at pH 6 and pH 8.
- According to the guideline OECD No. 29, temperature of the reaction vessel should be controlled to +/- 2 °C in the range 20 - 25 °C.
Using a data-logger into the mechanical shaker, the measured temperatures were outside the required range as temperatures ranged:
from 22.4 °C to 32.7 °C with a mean value 28.9 °C in the screening test,
from 23.6 °C to 26.6 °C with a mean value of 24.9 °C in the 7-d test, and
from 18.5 °C to 24.8 °C with a mean of 21.1 °C in the 28-d test.
- The between-vessel variation for the solution with pH 6 after 4 days and 7 days in the 7d-full test and for the solution after 7 days and 14 days in the 28d-full test were not less than the 20 % recommended by OECD Series No. 29.
- The 28-day test with a loading of 1 mg/L was conducted at pH 8 instead of 8.5
- `mass balance (%) after completion of the transformation test´ is missing - GLP compliance:
- yes
- Type of method:
- flask method
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 11.5 µg/L
- Element analysed:
- Sn
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH8
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- < 0.5 µg/L
- Element analysed:
- Cr
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH8
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 5.4 µg/L
- Element analysed:
- Sn
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 6
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- < 0.5 µg/L
- Element analysed:
- Cr
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH6
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 1.6 µg/L
- Element analysed:
- Sn
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- pH 6, 22.1 °C
- Remarks on result:
- other: S.D.: 0.5 µg Sn/L
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- > 0.5 - < 1 µg/L
- Element analysed:
- Cr
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- pH 6, 22.1 °C
- Remarks on result:
- other:
LOD (>0.5 µg/L) - Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 19.6 µg/L
- Element analysed:
- Sn
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- pH 8, 22.2 °C
- Remarks on result:
- other: S.D.: 0.7 µg Sn/L
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- < 0.5 µg/L
- Element analysed:
- Cr
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- pH 8, 22.2 °C
- Remarks on result:
- other:
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- < 0.5 µg/L
- Element analysed:
- Cr, Sn
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH: 8, Temp.: 20.0 °C
- Remarks on result:
- other: < LOD (0.05 µg/L)
- Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 2.2 µg/L
- Element analysed:
- Sn
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- pH 8, 20.4 °C
- Remarks on result:
- other: S.D.: 0.5 µg Sn/L
- Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- < 0.5 µg/L
- Element analysed:
- Cr
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- pH 8, 20.4 °C
- Remarks on result:
- other:
- Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 3.8 µg/L
- Element analysed:
- Sn
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 28 d
- Test conditions:
- pH 8, 20.0 °C
- Remarks on result:
- other: S.D.: 0.7 µg Sn/L
- Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- < 0.5 µg/L
- Element analysed:
- Cr
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 28 d
- Test conditions:
- pH 8, 20.0 °C
- Remarks on result:
- other: < LOD (0.5 µg/L)
- Details on results:
- For the 7 d and 28 d full tests, the increased between-vessel variation may be due to a particle size distribution of the test item (D10 = 1.7 µm, D50 = 3.8 µm and D90 = 7.4 µm, as per test item Certificate of Analysis) and the corresponding total surface area range that are not as narrow as requested in the OECD Series No. 29 and may result in higher variation.
The precision and the accuracy of the analytical method are in accordance with SANCO/3029/99 rev. 4.
The analytical method was suitable for the determination of chromium and tin in aqueous samples applying ICP-MS.
The analysed range, from 0.1 to 200 µg/L, was found to be linear for chromium and tin, respectively (correlation coefficient > 0.99).
The instrumental limit of detection (IDL) defined as the lowest calibration level, was 0.1 µg/L for chromium and tin, respectively.
The limit of quantification (LOQ) of the method was 1 µg/L for chromium and tin, respectively, defined as the lowest fortification level.
The limit of detection (LOD) of the method, defined as 50 % of the lowest fortification level, was 0.5 µg/L for chromium and tin, respectively.
Concentrations lower than the LOD were classified as not detected (n.d.).
Concentrations higher than the LOD but lower than the LOQ were designated as <1 µg/L for chromium and tin, respectively.
From the results of the accuracy test it can be concluded that there was not a matrix effect and contamination (e.g. by the filter procedure) did not occur during sample processing. - Conclusions:
- For the 7-d and 28-d full tests, the increased between-vessel variation may be due to a particle size distribution of the test item (D10 = 1.7 µm, D50 = 3.8 µm and D90 = 7.4 µm, as per test item Certificate of Analysis) and the corresponding total surface area range that are not as narrow as requested in the OECD Series No. 29 and may result in higher variation.
The transformation/dissolution of chrome tin pink sphene was measured according to the method OECD test series No. 29 (Guidance document on transformation/dissolution of metals and metal compounds in aqueous media). The transformation/dissolution of the pigment resulted in the following dissolved concentrations:
Full test 7 days at 100 mg/L and pH6: 1.6 ± 0.5 µg Sn/L and >0.5 <1.0 µg Cr/L
Full test 7 days at 100 mg/L and pH8: 19.6 ± 0.7 µg Sn/L and <0.5 µg Cr/L
Full test 7 days at 1 mg/L and pH8: 2.2 ± 0.5 µg Sn/L and <0.5 µg Cr/L
Full test 28 days at 1 mg/L and pH8: 3.8 ± 0.7 µg Sn/L and <0.5 µg Cr/L
Reference
Summary results for the 24h-screening test
Screening Test at 100 mg/L |
|
Cr (µg/L) |
Sn (µg/L) |
Solution pH 6 T24h |
Mean |
n.d. |
5.4 |
SD |
- |
0.2 |
|
RSD (%) |
- |
3.8 |
|
Solution pH 8 T24h |
Mean |
n.d. |
11.5 |
SD |
- |
0.8 |
|
RSD (%) |
- |
6.6 |
Abbreviations:
SD: Standard Deviation; RSD (%): Relative Standard Deviation %
n.d.: lower than the method Limit of Detection (LOD) (0.5 µg/L for Cr).
Summary results for the 7d-full test with a loading of 100 mg/L
Full test 7 days at 100 mg/L |
|
Cr (µg/L) |
Sn (µg/L) |
Solution pH 6 T1d |
Mean |
n.d. |
3.3 |
SD |
- |
0.7 |
|
RSD (%) |
- |
22.5(*) |
|
Solution pH 6 T4d |
Mean |
n.d. |
2.1 |
SD |
- |
0.3 |
|
RSD (%) |
- |
16.3 |
|
Solution pH 6 T7d |
Mean |
<1 |
1.6 |
SD |
- |
0.5 |
|
RSD (%) |
- |
30.5(*) |
|
Solution pH 8 T1d |
Mean |
n.d. |
4.9 |
SD |
- |
0.6 |
|
RSD (%) |
- |
11.7 |
|
Solution pH 8 T4d |
Mean |
n.d. |
12.4 |
SD |
- |
0.4 |
|
RSD (%) |
- |
3.3 |
|
Solution pH 8 T7d |
Mean |
n.d. |
19.6 |
SD |
- |
0.7 |
|
RSD (%) |
- |
3.3 |
n.d.: lower than the method Limit of Detection (LOD) (0.5 µg/L for Cr and Sn, respectively).
<1: lower than the method Limit of Quantification (LOQ) (1 µg/L for Cr) but higher than the method Limit of Detection (LOD) (0.5 µg/L for Cr).
(*)The between-vessel variation for solution with pH 6 after 4 days and 7 days were not less than the 20 % recommended by OECD Series No. 29.
Summary results for the 28d-full test with a loading of 1 mg/L
Full test 28 days at 1 mg/L |
|
Cr (µg/L) |
Sn (µg/L) |
Solution pH 8 T1d |
Mean |
n.d. |
n.d. |
SD |
- |
- |
|
RSD (%) |
- |
- |
|
Solution pH 8 T7d |
Mean |
n.d. |
2.2 |
SD |
- |
0.5 |
|
RSD (%) |
- |
23.1(*) |
|
Solution pH 8 T14d |
Mean |
n.d. |
3.1 |
SD |
- |
0.7 |
|
RSD (%) |
- |
21.3(*) |
|
Solution pH 8 T28d |
Mean |
n.d. |
3.8 |
SD |
- |
0.7 |
|
RSD (%) |
- |
18.7 |
n.d.: lower than the method Limit of Detection (LOD) (0.5 µg/L for Cr and Sn, respectively).
(*)The between-vessel variation after 7 days and 14 days were not less than the 20% recommended by OECD Series No. 29.
Analytical method (Inductively-Coupled-Plasma Mass-Spectrometry ICP-MS)
Specificity
Chromium and tin concentrations of blanks from each test medium were analysed. Chromium and tin concentrations in blanks of the respective media were below the method LOD.
Linearity and System Precision
The analysed range of Cr and Sn concentrations, from 0.1 µg/L to 50 µg/L,was found to be linear (correlation coefficient > 0.99 for each metal).
Since the fortification levels for the recovery test were 1 mg/L and 10 mg/L, the linear calibration performed for recovery quantification ranged from 0.1 µg/L to 50 µg/L.
Parameters of linear calibration for Cr analysis:
m (slope): 0.9326
q (intercept): 0.0457
R²(correlation):0.9999
Parameters of linear calibration for Sn analysis:
m (slope): 0.0149
q (intercept): 0.0002
R²(correlation): 0.9999
Repeatability (Precision) and Accuracy (Recovery)
For precision, the SANCO/3029/99 rev. 4 guideline requires an RSD to be lower than 20 % for each fortification level.
For accuracy, the SANCO/3029/99 rev. 4 guideline requires mean recovery values for each fortification level in the range from 70 to 110 %, ideally with the mean in the range 80 to 100 %.
Repeatability and Recovery test: Test medium at pH 6
Elution medium pH 6 |
Cr (µg/L) (1) |
Cr Recovery (%) |
Sn (µg/L) (1) |
Sn Recovery (%) |
Solution blank |
n.d. |
- |
n.d. |
- |
Spike L1 |
0.96 |
95.82 |
0.78 |
78.07 |
Spike L2 |
0.98 |
97.95 |
0.77 |
77.42 |
Spike L3 |
0.98 |
98.40 |
0.76 |
76.06 |
Mean value: |
1.0 |
97.4 |
0.8 |
77.2 |
Standard deviation (SD): |
0.01 |
1.38 |
0.01 |
1.03 |
Relative Standard deviation (RSD (%)): |
1.4 |
1.4 |
1.3 |
1.3 |
Elution medium pH 6 |
Cr (µg/L) (1) |
Cr Recovery (%) |
Sn (µg/L) (1) |
Sn Recovery (%) |
Solution blank |
n.d. |
- |
n.d. |
- |
Spike H1 |
9.38 |
93.78 |
8.21 |
82.10 |
Spike H2 |
9.30 |
92.96 |
8.33 |
83.26 |
Spike H3 |
9.78 |
97.82 |
7.92 |
79.24 |
Mean value: |
9.5 |
94.9 |
8.2 |
81.5 |
Standard deviation (SD): |
0.26 |
2.60 |
0.21 |
2.07 |
Relative Standard deviation (RSD (%)): |
2.7 |
2.7 |
2.5 |
2.5 |
(1) Mean of two determinations.
n.d.: lower than the method Limit of Detection (LOD) (0.5 µg/L for Cr and Sn, respectively).
Repeatability and Recovery test: Test medium at pH 8
Elution medium pH 8 |
Cr (µg/L) (1) |
Cr Recovery (%) |
Sn (µg/L) (1) |
Sn Recovery (%) |
Solution blank |
n.d. |
- |
n.d. |
- |
Spike L1 |
0.99 |
98.95 |
0.77 |
77.20 |
Spike L2 |
1.00 |
99.73 |
0.79 |
79.10 |
Spike L3 |
1.00 |
100.30 |
0.78 |
78.15 |
Mean value: |
1.0 |
99.7 |
0.8 |
78.1 |
Standard deviation (SD): |
0.01 |
0.68 |
0.01 |
0.95 |
Relative Standard deviation (RSD (%)): |
0.7 |
0.7 |
1.2 |
1.2 |
Elution medium pH 8 |
Cr (µg/L) (1) |
Cr Recovery (%) |
Sn (µg/L) (1) |
Sn Recovery (%) |
Solution blank |
n.d. |
- |
n.d. |
- |
Spike H1 |
9.51 |
95.06 |
7.92 |
79.18 |
Spike H2 |
9.46 |
94.56 |
7.93 |
79.27 |
Spike H3 |
9.93 |
99.27 |
8.33 |
83.28 |
Mean value: |
9.6 |
96.3 |
8.1 |
80.6 |
Standard deviation (SD): |
0.26 |
2.58 |
0.23 |
2.34 |
Relative Standard deviation (RSD (%)): |
2.7 |
2.7 |
2.9 |
2.9 |
(1) Mean of two determinations.
n.d.: lower than the method Limit of Detection (LOD) (0.5 µg/L for Cr and Sn, respectively).
Description of key information
The solubility of Chromium tin calcium silicon sphene is < 0.02 wt%. A GLP-conform transformation/dissolution test with a loading of 100 mg/L at pH6 and ph8 over 7 days, revealed higher dissolution at ph 8 than at pH6. Dissolved Cr and Sn concentration at pH8 after 7 days were below LOD (0.5 microg/L) and 19.6 microg/L, respectively. Transformation/dissolution at a loading of 1 mg/L at pH8 over 28 days resulted in dissolved Cr concentrations below < LOD (0.5 mircog/L) after 7 and 28 days. Whereas dissolved Sn concentrations were detected at 2.2 microg/L and 3.8 microg/L after 7 and 28 days, respectively (Pardo Martinez, 2013).
The particle size of the tested sample (BET surface area 1.9 m2/g) is representative for the particle size on the market. Thus, the extent to which "Chromium tin calcium silicon sphene" can produce soluble available ionic and other metal-bearing species in aqueous media is limited.
Key value for chemical safety assessment
Additional information
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