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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-423-8 | CAS number: 95-48-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Specific investigations: other studies
Administrative data
- Endpoint:
- mechanistic studies
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: in silico model, reliability of limited significance
Data source
Reference
- Reference Type:
- publication
- Title:
- Calculating the dermal flux of chemicals with OELs based on their molecular structure: An attempt to assign the skin notation
- Author:
- Kupczewska-Dobecka M, Jakubowski M, Czerczak S
- Year:
- 2 010
- Bibliographic source:
- Environmental Toxicology and Pharmacology 30 (2010) 95–102
Materials and methods
- Principles of method if other than guideline:
- The permeability coefficient and dermal penetration rates (flux value) for 112 chemicals with occupational exposure limits (OELs) was calculated according to the LFER (linear free-energy relationship) model using published methods. To assign skin notations based on each chemical’s molecular structure was also attempted.
- GLP compliance:
- no
- Type of method:
- other: in silico model
- Endpoint addressed:
- dermal absorption
Test material
- Reference substance name:
- 95-58-7
- IUPAC Name:
- 95-58-7
- Details on test material:
- not applicable - in silico model
Constituent 1
Test animals
- Species:
- other: not applicable - in silico model
- Strain:
- other: not applicable - in silico model
Administration / exposure
- Route of administration:
- other: not applicable - in silico model
- Vehicle:
- other: not applicable - in silico model
- Duration of treatment / exposure:
- not applicable - in silico model
- Frequency of treatment:
- not applicable - in silico model
- Post exposure period:
- not applicable - in silico model
- No. of animals per sex per dose:
- not applicable - in silico model
Results and discussion
- Details on results:
- Chemical CAS No. OEL [mg/l] Fl* [mg/cm2/h] Log Kp ABR [cm/h] Fl ABR [mg/cm2 /h] Fl*/Fl
o-Cresol 108-39-4 0.0220 0.0165 −1.6610 0.5457 0.0302 m-Cresol 95-48-7 0.0220 0.0165 −1.6610 0.5129 0.0322 p-Cresol 106-44-5 0.0220 0.0165 −1.6610 0.5239 0.0315
-fluxes (Fl, mg/cm2/h) and permeability coefficient values (Log Kp cm/h), calculated from the Abraham and Martins model
-critical fluxes (Fl*, mg/cm2h) and the critical flux to calculated flux (Fl*/Fl) ratio
Applicant's summary and conclusion
- Executive summary:
The permeability coefficient and dermal penetration rates (flux value) for 112 chemicals with occupational exposure limits (OELs) was calculated according to the LFER (linear free-energy relationship) model using published methods.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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