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Diss Factsheets
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EC number: 240-347-7 | CAS number: 16219-75-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
ENB has a relatively low degree of acute toxicity in several species via oral and dermal but has significant toxicity by the inhalation route of administration.
Oral LD50: All rat. male: 2276mg/kg, female: 5071mg/kg, sex not specified: 2.83, 3.08, 3.125ml/kg
Inhalation LC50: Rat male: 6.23, 13.5mg/l, female: 11.25, 15.1mg/l. Mouse: male 5.5 mg/l, female 3.7mg/l. Rabbit male: 15.5mg/l. Guinea pig male: 14.4mg/l
Dermal, rabbit LD50: 5.66 ,>8, 9.17ml/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 200 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
There are a number of acute toxicity studies on ENB by the inhalation route, the oral route and the dermal route. The data described in Ballantyne et al (1997) were selected as the key studies since the analytical purity of the ENB was specified and because they are well reported studies. The acute oral LD50value was 2276 mg/kg for male rats and 5071 mg/kg for female rats. The acute inhalation LC50values were 13.3 mg/L (2717 ppm) for male rats and 14.8 mg/L (3015 ppm) for female rats. The dermal LD50value was greater than 7168 mg/kg for male and female rabbits.
Justification for classification or non-classification
Based on the available animal data, there is sufficient information available to determine that no classification is required for the oral and dermal routes of acute exposure.
For the inhalation route, the data available indicates that classification as acute toxicity category 4 is required base on data from the rat (3 of 4 studies including the LT50 studies), rabbit and guinea pig (average of results from all studies and sexes). The data on mice suggests a more severe effect. A classification based on the response in the majority of species and the preferred species for this end point, therefore a classification of harmful seems most appropriate. This is supported by the observation that the range of LC50 values span the range 13 -56% of the saturated vapour concentration at 20C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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