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EC number: 215-266-5 | CAS number: 1317-35-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A non-GLP study conducted to sound scientific principles with a sufficient level of detail to assess the quality of the relevant results.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of feeding manganese antiknock gasoline additive exhaust residues (manganese (III) oxide) in rats
- Author:
- Exon JH and Koller LD
- Year:
- 1 975
- Bibliographic source:
- Bulletin of Environmental Contamination, 14(3): 370-3
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 28-day repeat dose via oral route.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Trimanganese tetraoxide
- EC Number:
- 215-266-5
- EC Name:
- Trimanganese tetraoxide
- Cas Number:
- 1317-35-7
- Molecular formula:
- Mn3O4
- IUPAC Name:
- trimanganese tetraoxide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
200000, 20000, 2000, 200 or 0 ppm
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
1750 mg/kg bw (week 1) then 7500 to 8900 mg/kg bw during weeks 2,3,4 (Group I)
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
630-1220 mg/kg bw over weeks 1-4 (Group 2)
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
70-110 mg/kg bw over weeks 1-4 (Group 3)
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
4-13 mg/kg bw over weeks 1-4 (Group 4)
Basis:
nominal in diet
- No. of animals per sex per dose:
- 4 males per dose group
- Control animals:
- yes, plain diet
Examinations
- Observations and examinations performed and frequency:
- -bodyweight was recorded twice weekly.
-food consumption and signs of clinical abnormalities. - Sacrifice and pathology:
- All rats were sacrificed after 28 days. Sections of tissues (lung, heart, spleen, liver, kidney, brain, adrenal gland, intestine, muscle and spinal cord) were fixed and examined microscopically for histopathological changes.
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Food efficiency:
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Gross pathological findings:
- no effects observed
- Details on results:
- -Food Consumption: Rats in the highest dose group consumed less than one-half as much feed as rats in other groups.
-Bodyweight gain: Rats in highest dose group steadily lost weight throughout the experiment.
-Mortality: No mortalities in any dose group.
-Clinical signs: Rats in highest dose group were emaciated, lethargic and hypersensitive to handling. After 28 days of exposure these conditions were more pronounced.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- < 9 mg/kg bw/day (nominal)
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Mn3O4 fed to rats for 28 days showed low oral toxicity, even at doses as high as 8900 mg Mn3O4/kg bw/day.
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