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Diss Factsheets
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EC number: 235-759-9 | CAS number: 12656-85-8 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77605.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable publication (Ames test at only one concentration level - spot test, no S-9 activation, only S. typhimurium used)
Data source
Reference
- Reference Type:
- publication
- Title:
- Study of 106 organic and inorganic compounds in the Salmonella/microsome test.
- Author:
- De Flora S
- Year:
- 1 981
- Bibliographic source:
- Carcinogenesis 2: 283-298
Materials and methods
- Principles of method if other than guideline:
- Ames test (spot test, because of the low solubility of the test substance; i.e. placement of 2 mg of the test material in the middle of a plate)
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Molybdenum Orange
- IUPAC Name:
- Molybdenum Orange
- Details on test material:
- - Name of test material (as cited in study report): Molybdenum Orange (or lead solfomolybdochromate), industrial grade
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: PbCrO4, 72-77%; PbSO4, 4-6%; Al2O4, 2%; PbMoO4, 12-14%
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA 98, 100, 1535, 1537 and 1538
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 2 mg (spot test)
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO (at -1.4x10E6 nmoles/plate) or water (not clearly specified)
- Justification for choice of solvent/vehicle: solubility
Controls
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- other: addtional compounds (total of 106) were also tested, some showing negative results
- Positive controls:
- yes
- Positive control substance:
- other: a couple of polycyclic aromatic hydrocarbons were also tested, including benzo(a)pyrene and benz(a)anthracene
- Details on test system and experimental conditions:
- spot test according to Ames et al, Mutat Res 31: 347-364; no addtional information
- Evaluation criteria:
- clearly positive result indicated by a dose- related and reproducible increase of his+ revertant over controls (at least a 3-fold increase ); weak positivity indicated by an increase of revertants 2 to 3 times the controls; ambiguous response indicated by reproducible but less than 2-fold increase of revertants; negative result indicated by no conclusive experiment carried out with the corresponding strain.
- Statistics:
- no data
Results and discussion
Test results
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Remarks:
- only TA 100
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: other: Salmonella typhimurium TA 98, 100, 1535, 1537 and 1538
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
The test substance proved positive only in S. typhimurium TA100 strain.It is also stated that the test substance was positive in the plate test, when solubilized in 0.5 M sodium hydroxide (statement without any further specification, for example concerning the bacterial strains used).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.