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EC number: 204-622-5 | CAS number: 123-35-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Old study conducted similarly to OECD Guideline 402 with minor deviations: few data about test substance and test conditions, skin was abraded.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Few data about test substance and test conditions, skin was abraded.
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 7-methyl-3-methyleneocta-1,6-diene
- EC Number:
- 204-622-5
- EC Name:
- 7-methyl-3-methyleneocta-1,6-diene
- Cas Number:
- 123-35-3
- Molecular formula:
- C10H16
- IUPAC Name:
- 7-methyl-3-methylideneocta-1,6-diene
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1.7 to 2.4 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
The test substance was applied at 5 g/kg bw on clipped abraded abdominal skin. The animals were wrapped with binders of rubber dam, gauze and adhesive tap.
Folllowing exposure, the binders were removed and observations were made. - Duration of exposure:
- 24 hours
- Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Animals were observed frequently for mortality for 14 days. Body weights were recorded at pre and post-treatment.
- Necropsy of survivors performed: Yes - Statistics:
- None
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No evidence of systemic toxicity. Signs of irritation were noted (see table 1).
- Gross pathology:
- No abnormalities were noted upon gross necropsy.
- Other findings:
- None
Any other information on results incl. tables
Table 1: signs of dermal irritation in rabbits following a 24-h exposure with myrcene
Observation day |
Erythema |
Edema |
1 |
++ (8) + (2) |
++ (9) + (1) |
2 |
++ (5) + (5) |
++ (5) + (5) |
3 |
++ (3) + (6) |
++ (3) + (6) |
4 |
++ (1) + (7) |
++ (2) + (6) |
5 |
+ (5) |
+ (4) |
6 |
- |
+ (2) |
7 |
- |
- |
8 |
- |
- |
9 |
- |
- |
10 |
- |
- |
11 |
- |
- |
12 |
- |
- |
13 |
- |
- |
14 |
- |
- |
+ : slight ; ++ : moderate ; number in parentheses = number of animals showing sign
Table 2: bodyweights before and after treatment
Animal number |
Pre-treatment (kg) |
Post-treatment (kg) |
1 |
2.0 |
1.9 |
2 |
1.7 |
1.8 |
3 |
1.9 |
2.0 |
4 |
2.0 |
1.9 |
5 |
2.4 |
2.4 |
6 |
2.0 |
2.0 |
7 |
1.8 |
1.8 |
8 |
2.1 |
2.0 |
9 |
2.2 |
2.1 |
10 |
2.2 |
2.2 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 of myrcene was greater than 5 g/kg bw.
- Executive summary:
In an acute dermal toxicity study performed similarly to OECD guideline 402, a group of 10 New Zealand White rabbits received a single dermal dose of myrcene at 5 g/kg on clipped abraded abdominal skin in occlusive conditions for 24 h. All animals were observed for mortality and skin reactions for 14 days. No mortality was observed. No changes in bodyweight related to treatment could be observed. No signs of systemic toxicity were observed. All animals showed slight to moderate erythema and edema during the first days after exposure that were completely reversed after 7 days.No abormalities were noted upon gross necropsy. Therefore, the acute dermal LD50 was greater than 5 g/kg bw.
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