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EC number: 200-712-3 | CAS number: 69-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Mechanisms regulating toxicant deposition to the embryo during early pregnancy: an interspecies comparison
- Author:
- Carney EW, Scialli AR, watson RE, deSesso JM
- Year:
- 2 005
- Bibliographic source:
- Birth Defects Research (Part C) 72, 345-360
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Determination of salicylate concentration in maternal and foetal tissues on intravenous administration.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Salicylic acid
- EC Number:
- 200-712-3
- EC Name:
- Salicylic acid
- Cas Number:
- 69-72-7
- Molecular formula:
- C7H6O3
- IUPAC Name:
- 2-hydroxybenzoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Results and discussion
Any other information on results incl. tables
Administration of salicylate to pregnant rats by intravenous infusion was associated with five-fold higher concentrations to total salicylate in maternal plasma than in the embryo, visceral sac, or extraembryonic fluid on GD 12.5. However, the proportion of free salicylate was slightly higher in the embryo than in maternal blood, consistent with ion trapping. By contrast, at term, total maternal plasma salicylate was only about twice the level of fetal blood salicylate.
The authors attributed the lower maternal:fetal salicylate ratio at term to decreased maternal protein binding closer to term, with free salicylate levels increasing from 14 to 27% between GD 12.5 and GD 20.5.
Applicant's summary and conclusion
- Executive summary:
In rats, salicylic acid transfer across the placenta appears to be influenced both by ion trapping and protein binding. Clearance of salicylate from the near-term fetus across the placenta to the more alkaline maternal compartment is greater than maternal transfer to the fetus. This phenomenon can be augmented by alkalinization of maternal blood. Administration of salicylate to pregnant rats by intravenous infusion (to maintain constant maternal blood levels) was associated with five-fold higher concentrations to total salicylate in maternal plasma than in the embryo, visceral sac, or extraembryonic fluid on GD 12.5. However, the proportion of free salicylate was slightly higher in the embryo than in maternal blood, consistent with ion trapping. By contrast, at term, total maternal plasma salicylate was only about twice the level of fetal blood salicylate. The authors attributed the lower maternal:fetal salicylate ratio at term to decreased maternal protein binding closer to term, with free salicylate levels increasing from 14 to 27% between GD 12.5 and GD 20.5.
The distribution of salicylate in near-term human pregnancy favours the fetus, with neonatal:maternal salicylate concentration ratios of about 1.6. The concentration gradient of high concentrations in the fetus relative to the mother was attributed to greater protein binding in the term fetus, with comparable concentrations of free salicylate in the two compartments.
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