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EC number: 206-696-4 | CAS number: 367-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 31 August to 01 December 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium mercaptoacetate
- EC Number:
- 206-696-4
- EC Name:
- Sodium mercaptoacetate
- Cas Number:
- 367-51-1
- Molecular formula:
- C2H4O2S.Na
- IUPAC Name:
- sodium sulfanylacetate
- Test material form:
- solid - liquid: suspension
- Details on test material:
- Description: sodium thioglycolate 98 %
Batch number: B00S5974
Purity: 99.9 %
Stability: Stable under storage conditions, under nitrogen
Stability of test item: Stable in bi-distilled water for a least 30 minutes.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- ANIMALS
- Source: RCC, Ltd, Biotechnology & Animal breeding division, Wölferstrasse, 4 CH-4414 Füllinsdorf , Switzerland.
- Age: 8-10 weeks
- Weight: 217.1-234.7 g (M), 158.9-181.9 g (F)
- Acclimatization: 1 week
- Housing: 3 per sex
- Diet: ad libitum Pelleted standard Kliba 3433, batch n° 03/00 and 04/00, rat maintenance diet (Provimi Kliba AG, CH-4303 Kaiseraugst)
- Water: ad libitum tap water
CONDITIONS:
- Air changes: 10-15/hour
- Temperature: 21-23.5 °C
- Relative Humidity: 36-57%
- Light-Dark cycle: 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The animals received a single dose of the test item on a 200, 50 or 25 mg/kg bw by oral gavage following fasting for approx. 17 hours, but with free access to water. Food was provided again 3 hours after dosing.
- Doses:
- 25, 50 and 200 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Animals were observed once daily during the acclimatization phase and then 1, 2, 3 and 5 hours after administration on day 1 and twice daily for surviving animals during days 2-15. Surviving animals were weighted on day 1, 8 and 15. All abnormalities and clinical signs were recorded. All animals were necropsied and examined macroscopically.
- Statistics:
- None
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 50 - <= 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All males and females treated at 25 and 50 mg/kg survived until scheduled necropsy. Two out of 3 females treated at 200 mg/kg died on day 1. The following animals were treated and percentage mortality was observed:
Males Females
Group 1 (200 mg/kg) 66%
Group 2 (50 mg/kg) 0%
Group 3 (50 mg/kg) 0%
Group 4 (25 mg/kg) 0%
Group 5 (25 mg/kg) 0% - Clinical signs:
- other: No clinical signs were observed during the observation period in all 50 mg/kg treated males and females and all 25 mg/kg treated females. Slightly ruffed fur was observed in all 200 mg/kg treated females from 1 to 3 hours (2 females) or from 1 or 5 ho
- Gross pathology:
- A distended stomach with gas was observed at the unscheduled necropsy in two females treated at 200 mg/kg. No macroscopic findings were observed at the other scheduled necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The median lethal dose is between 50 and 200 mg/kg in rat after a single oral administration in both sexes.
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