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Diss Factsheets
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EC number: 221-201-1 | CAS number: 3030-47-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (limited documentation on test substance, occlusive treatment, 2 dose levels tested only)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: 40 CFR, Section 163.81-2, Federal Register, August 22, 1978 and subsequently modified in accordance with the revised EPA Pesticide Assessment Guidelines of Nov 1982
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- GLP compliance statement available
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Polycat 5
- IUPAC Name:
- Polycat 5
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- Trade name of the test substance (from study report): Polycat 5
Analytical purity: no data
Lot No: AL6217-003
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: Perfection Breeders, Inc., Douglassville, PA 19518 (U.S.D.A. License 123-DG)
- Acclimating period: 5 days prior to exposure
- Animals housed individually, maintained in accordance with standards set forth in the Guide for the Care and Use of Laboratory Animals (DHEW Publica- tion No. 80-23).
- Temperature: 60°F - 75°F, Relative Humidity,%: 55 +/- 25, Light: 12 hour light/dark cycle
- Mean weight at study initiation: 2 - 3 kg
- Diet: Wayne 15% Rabbit Ration ad libitum
- Water: ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- Test site: back
Clipping of fur: 24 h before application
Area of exposure: ca. 10% of body surface
Type of wrap used: porous gauze patch wrapped with an impervious material.
Removal of the test substance: using water or an appropriate solvent, 24 h after the start of exposure - Duration of exposure:
- 24 hours
- Doses:
- 200 and 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Rabbits (5 animals per sex/dose) were individually housed and maintained in accordance with standards set forth in the Guide for the Care and Use of Laboratory Animals (DHEW Publica- tion No. 80-23). The rabbits were acclimated to the laboratory for at least 5 days prior to dosing. healthy intact skin were used. Approximately 24 hours before testing, the fur was clipped from the backs of the test animals. Test Article was applied to approximately 10% of the body surface on each animal. The dressings were removed after 24 hours . Two dose levels were tested. The animals were observed for a 14 day period for signs of toxicity (systemic and topical) and for mortalities.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 1 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- exposure 200 mg/kg bw (males and females) - no mortality
exposure 1000 mg/kg bw - 4/5 males, 3/5 females - Clinical signs:
- other: Males: - 200 mg/kg bw - signs of necrosis on the skin in all animals - 1000 mg/kg bw - signs of necrosis on the skin in all animals, signs of diarrhea in 1 animal Females: - 200 mg/kg bw - signs of necrosis on the skin in all animals - 1000 mg/kg bw - s
- Gross pathology:
- Males:
- 200 mg/kg bw - no findings
- 1000 mg/kg bw - pale kidneys and liver noted for the 1/5 animals found dead on day 3. Enlarged and pale kidneys noted for 2/5 animals found dead on day 4.
Females:
- 200 mg/kg bw - no findings
- 1000 mg/kg bw - pale kidneys and liver noted for the 1/5 animals found dead on day 3. Enlarged and pale kidneys noted for 2/5 animals found dead on day 4.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.