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Diss Factsheets
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EC number: 938-677-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Repeat Dose Oral Toxicity:
This endpoint has been addressed using the read-across category approach to the surrogate substance ammonium zirconium carbonate.
NOEL 1000 mg/kg/day, rat, OECD 422, Marr (2010).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- The study was performed to a good standard with a sufficient level of information to assign a reliability score of 2 according to the principles for assessing data quality set out in Klimisch (1997).
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Repeat Dose Toxicity - Oral
The repeat dose toxicity of the test material has been addressed using the read across category approach to Ammonium Zirconium Carbonate. Marr (2010) has been provided as the key study, which was performed according to GLP and the standardised guideline OECD 422. Oral administration of Ammonium Zirconium Carbonate to rats for a period of up to forty-five consecutive days at dose levels of up to 1000 mg/kg/day did not result in any treatment-related systemic effects. Therefore, the NOEL was considered to be 1000 mg/kg/day for systemic toxicity.
Repeat Dose Toxicity - Inhalation
In accordance with section 1 of REACH Annex XI repeated dose toxicity testing by inhalation administration (as required in section 8.6.1) does not appear scientifically necessary. Oral dosing of the surrogate substance, ammonium zirconium carbonate, to rats for a period of up to forty-five consecutive days at dose levels of up to the limit dose of 1000 mg/kg/day did not result in any toxicologically significant effects. Bearing in mind the low potential for inhalation exposure through manufacture and use of the substance and the possibility to predict low inhalation toxicity in the event of repeated exposure it is not considered justified to undertake an additional study.
Repeat Dose Toxicity - Dermal
In accordance with section 1 of REACH Annex XI repeated dose toxicity testing by dermal administration (as required in section 8.6.1) does not appear scientifically necessary. Oral dosing of the surrogate substance, ammonium zirconium carbonate, to rats for a period of up to forty-five consecutive days at dose levels of up to the limit dose of 1000 mg/kg/day did not result in any toxicologically significant effects. Additionally, no signs of systemic toxicity were observed in an acute dermal toxicity study (limit test at 2000 mg/kg). Bearing in mind the low potential for dermal exposure through manufacture and use of the substance and the possibility to predict low dermal toxicity in the event of repeated exposure it is not considered justified to undertake an additional study.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
The key study (Marr, 2010) was performed on a surrogate substance and has been provided on the basis of read-across given the substances common ionic components, ZrO2. The study was performed using ammonium zirconium carbonate in a GLP compliant study conducted according to OECD guideline 422.
Justification for classification or non-classification
In accordance with the criteria for classification as defined in Annex I, Regulation 1272/2008, the test material does not require classification for repeated dose toxicity.
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