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Diss Factsheets
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EC number: 249-978-2 | CAS number: 29964-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Results of the repeated dose studies on the structurally closely related esters 2-Ethylhexyl methacrylate (C8-Ester) and Dodecyl methacrylate
(C12-Ester) are considered as representative for the repeated dose toxicity of Isodecyl methacrylate (C10-Ester).
In an OECD 422 GLP study with Dodecyl methacrylate in rats, there was no evidence for toxicity up to the highest administered dose.
The NOAEL was 1000 mg/kg/d. In a fully valid 90 d OECD 408 GLP study with 2-Ethylhexyl methacrylate, the NOAEL was 120 mg/kg body weight/day in rats.
Taken as a whole there are sufficient data available for assessment purposes so for the sake of animal welfare it is not proposed to conduct further
repeated dose studies.
Key value for chemical safety assessment
Additional information
For alkyl methacrylate esters in principal and especially for the structurally closely related esters 2-Ethylhexyl methacrylate and Dodecyl methacrylate, there is strong and consistent evidence for a uniform metabolism (Jones, 2002, cf chapter 7.1.1). The first step is always cleavage of the ester to methacrylic acid and the regarding alcohol catalyzed by unspecific esterases which are present in all tissues relevant for metabolism, including liver, skin and lung tissues. Thereafter, the acid is further metabolised via the valine pathway of the citric acid cycle and the alcohol may be further metabolised by the standard metabolic pathways for fatty alcohols. Consequently, results of the repeated dose studies on the structurally closely related esters 2-Ethylhexyl methacrylate (C8-Ester) and Dodecyl methacrylate (C12-Ester) are considered as representative for the repeated dose toxicity of Isodecyl methacrylate (C10-Ester).
In an OECD 422 GLP study with Dodecyl methacrylate in rats, there was no evidence for toxicity up to the highest administered dose.The NOAEL was 1000 mg/kg/d. In a fully valid 90 d oral toxicity GLP study in rats according to OECD 408, 2-Ethylhexyl methacrylate revealed signs of general systemic toxicity in male as well as female rats at a dose level of 360 mg/kg/d. The NOAEL was 120 mg/kg/d.
Taken as a whole there are sufficient data available for assessment purposes so for the sake of animal welfare it is not proposed to conduct further repeated dose studies.
Justification for classification or non-classification
According to the criteria as of directive 1272/2008/EC, no classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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