Registration Dossier
Registration Dossier
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EC number: 201-058-1 | CAS number: 77-78-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Significant methodological deficiencies: the way of application (i.p., i.v., s.c.) is not relevant for exposure. Only short study summary: details of test item (purity, stability, etc), justification for vehicle choice and details of response data by dose level for every test animal are missing
Data source
Reference
- Reference Type:
- publication
- Title:
- Reaktivität und Toxizität cyclischer Schwefelsäureester
- Author:
- Fischer, G.W. et al.
- Year:
- 1 975
- Bibliographic source:
- J. Prakt. Chemie 317, 943-952
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl sulphate
- EC Number:
- 201-058-1
- EC Name:
- Dimethyl sulphate
- Cas Number:
- 77-78-1
- Molecular formula:
- C2H6O4S
- IUPAC Name:
- dimethyl sulfate
- Details on test material:
- - Name of test material (as cited in study report): Dimethyl sulphate
No further details are given.
Constituent 1
Test animals
- Species:
- other: mouse (1) and rat (2)
- Strain:
- other: Strong A (mouse)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- other: intraperitoneal, intravenous and subcutan
- Vehicle:
- other: sunflower oil (0.1 mL solution/10 g mouse)
- Details on exposure:
- No data
- Doses:
- No data
- No. of animals per sex per dose:
- 8 (mouse)
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- No data
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 61 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: mouse; intraperitoneal
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 90 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: rat; intravenous
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 100 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: rat; subcutan
- Mortality:
- No data
- Clinical signs:
- No data
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Conclusions:
- LD50 (mouse, intraperitoneal) for dimethyl sulphate is 62 mg/kg bw.
LD50 (rats, intravenous) for dimethyl sulphate is 90 mg/kg bw.
LD50 (rats, subcutanl) for dimethyl sulphate is 100 mg/kg bw.
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