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EC number: 614-074-2 | CAS number: 675106-31-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- oxo[(oxoalumanyl)oxy]alumane
- EC Number:
- 614-074-2
- Cas Number:
- 675106-31-7
- Molecular formula:
- UVCB
- IUPAC Name:
- oxo[(oxoalumanyl)oxy]alumane
- Test material form:
- solid: fibres
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- Aluminium content assessed in test samples using ICP-MS
- Details on sampling:
- Water samples were taken from the control and 100% v/v saturated solution test vessel at 0, 24, 48 and 72 hours from fresh media and at 24, 48, 72 and 96 hours from old media for quantitative analysis. The 0, 24, 48 and 72-Hour samples were stored frozen prior to analysis with the 96-Hour samples.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- A nominal amount of test item (1100 mg) was dispersed in 22 L of test water with the aid of propeller stirring at approximately 1500 rpm for 24 hours. After 24 hours the stirring was stopped and any undissolved test item was removed by filtration through a 0.2 μm Sartorius Sartopore filter (first approximate 1 L used to pre-condition the filter was discarded) to give a 100% v/v saturated solution.
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Strain: Not applicable
- Source: Brow Well Fisheries Limited, Hebden, near Skipton, Yorkshire, UK
- Age at study initiation (mean and range, SD): Not specified
- Length at study initiation (length definition, mean, range and SD): 4.8 cm (SD = 0.2)
- Weight at study initiation (mean and range, SD): 0.85 g (SD 0.11)
- Method of breeding: Not at test site.
- Maintenance of the brood fish: Not applicable
ACCLIMATION
- Acclimation period: 5 to 12 April 2021
- Acclimation conditions (same as test or not): Same as test
- Type and amount of food during acclimation: Commercial trout pellets
- Feeding frequency during acclimation: Not specified
- Health during acclimation (any mortality observed): There were no mortalities in the 7 days prior to the start of the test
FEEDING DURING TEST (as applicable)
- Fish were not fed during the test and for around 26 hours ahead of the definitive test
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- Standard as per OECD Guidelines
- Post exposure observation period:
- None required
Test conditions
- Hardness:
- Approximately 140 mg/L as CaCO3
- Test temperature:
- 13 to 14°C
- pH:
- Control: 7.6 to 8.0
Test 100 % (v/v): 7.9 to 8.4 - Dissolved oxygen:
- Control: 10.3 to 11.7 mg O2/L
Test 100% (v/v): 10.1 to 10.9 mg O2/L - Salinity:
- Not specified
- Conductivity:
- Typically 513 μS/cm at 20 °C
- Nominal and measured concentrations:
- Nominal: Control and 0.045 mg/L as aluminium (100 % v/v, 50 mg/L)
Measured: Control and 0.016 mg/L as aluminium - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass aquaria
- Type (delete if not applicable): open although covered to reduce evaporation
- Material, size, headspace, fill volume: 20L in 25 to 30L aquaria
- Aeration: Aerated using narrow bore glass tubes
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): Not applicable
- Biomass loading rate: Not specified
TEST MEDIUM / WATER PARAMETERS
- The test water used for both the range-finding and definitive tests was the same as that used to maintain the stock fish.
Laboratory tap water was dechlorinated by passage through an activated carbon filter (Fleck 2750 Duplex Dechlorination unit) and partly softened (Elga Nimbus 1248D Duplex Water Softener) giving water with a total hardness of approximately 140 mg/L as CaCO3. After dechlorination and softening the water was passed through a series of computer controlled plate heat exchangers to achieve the required temperature.
OTHER TEST CONDITIONS
- Adjustment of pH: Not required
- Photoperiod: The lighting cycle was controlled to give a 16 hours light and 8 hours darkness cycle with 20 minute dawn and dusk transition periods.
- Light intensity: Not specified
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Any mortalities and sub-lethal effects of exposure were recorded at 1, 3, 6, 24, 30, 48, 53, 72, 78 and 96 hours after the start of exposure. The criteria of death were taken to be the absence of both respiratory movement and response to physical stimulation.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: Limit concentration
- Justification for using less concentrations than requested by guideline: Limit tests are acceptable in the OECD test guideline.
- Range finding study
- Test concentrations: In the range-finding test fish were exposed to a series of nominal test concentrations of 0.10, 1.0, 10 and 100% v/v saturated solution for a period of 96 hours.
- Results used to determine the conditions for the definitive study: The results showed no mortalities at the test concentrations of 0.10, 1.0, 10 and 100% v/v saturated solution. Based on this information, a single test concentration of 100% v/v saturated solution was selected for the definitive test. This experimental design conforms to a "Limit test" to confirm that at the highest attainable test concentration, no mortalities or sub-lethal effects of exposure were observed. - Reference substance (positive control):
- no
- Remarks:
- Not a guideline requirement
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LL50
- Effect conc.:
- > 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.016 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- element
- Remarks:
- Aluminium
- Basis for effect:
- mortality (fish)
- Details on results:
- Mortality: There were no mortalities in seven fish exposed to a test concentration of 0.016 mg/L as Aluminium for a period of 96 hours.
Sub-lethal effects: There were no sub-lethal effects of exposure observed in the test.
Verification of aluminium concentrations: The substance is considered as insoluble and a UVCB with variable composition (which includes aluminium) and as such was considered to be pure and as a result, a saturation solution approach was used. The results of the alumina release represent the test item as a whole, with relatively low levels of alumina released into the solution at saturation concentration reflecting the low inherent solubility of the substance despite high alumina content. Analysis of the test preparations at 0, 24, 48 and 72 hours fresh showed measured test concentrations to range from 0.015 to 0.018 mg/L as Aluminium. There was no significant change in the measured concentrations at 24, 48, 72 and 96 hours in the old media and so the results are based on the average fresh measured test concentration only. Due to the presence of Aluminium in the control in the original samples, duplicate test samples were analyzed. Duplicate samples confirmed Aluminium to be present in the control however, this is taken to be representative of normal levels in the test media. As a result of this and as a standard was removed in the calibration of the initial analysis, duplicate results were used for reporting. All measured concentrations in the test samples were corrected for control values due to the presence of Aluminium in the media. - Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- An estimate of the LC50 values was given by inspection of the mortality data.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Definitive test results (analytical verifications):
Sample description
Time point (Hours)
Concentration detected (mg/L Al)
Control
0
0.0132
100% (v/v) saturated solution
0.0183
Control
24 old
0.0145
100% (v/v) saturated solution
0.0227
Control
24 fresh
0.0141
100% (v/v) saturated solution
0.0162
Control
48 old
0.0124
100% (v/v) saturated solution
0.0173
Control
48 fresh
0.0112
100% (v/v) saturated solution
0.0159
Control
72 old
0.0126
100% (v/v) saturated solution
0.0142
Control
72 fresh
0.0111
100% (v/v) saturated solution
0.0148
Control
96 old
0.0114
100% (v/v) saturated solution
0.0150
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- The test was considered to be valid given that none of the control fish died or showed signs of stress during the test and that the oxygen concentration at the end of the test was ≥60% of ASV (6.2 mg O2/L) in the control and test vessels.
- Conclusions:
- The acute toxicity of the test item to the freshwater fish rainbow trout (Oncorhynchus mykiss) has been investigated and based on the average fresh measured test concentration gave a 96 hour LC50 of greater than 0.016 mg/L as Aluminium (> 50 mg/L as nominal loading rate).
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