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EC number: 204-010-8 | CAS number: 112-85-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 May - 15 May 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- According to Japanese GLP standard
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: Test water was directly sampled by each vessel.
- Sample storage conditions before analysis: No storage before analysis. - Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Test item was mixed with HCO-20 and diluted with dilution water (stock solution: 100 mg/L).
- Controls: Blank control and vehicle control
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): HCO-40
- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): 2000 mg/L in stock solution and 100 mg/L in final test solution - Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: Medaka fish
- Source: Sankyo Suisan Company, Shinjuku, Japan
- Length at study initiation (length definition, mean, range and SD): 2.33 cm (2.16 - 2.49 cm)
- Weight at study initiation (mean and range, SD): 0.226 g (0.162 - 0.318 g)
- Feeding during test: No food
ACCLIMATION
- Acclimation period: 27 February - 11 May 1998
- Acclimation conditions (same as test or not): Same as test
- Type and amount of food: Tetramin
- Health during acclimation (any mortality observed): Mortality was < 5% during 7 days before exposure - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 63 mg/L as CaCO3
- Test temperature:
- 23.5 - 24.2 °C
- pH:
- 7.2 - 7.8
- Dissolved oxygen:
- 5.2 - 8.3 mg/L
- Nominal and measured concentrations:
- Nominal concentration: 5 mg/L
Measured concentration: 4.93 mg/L (geometric mean) - Details on test conditions:
- TEST SYSTEM
- Test vessel: Beaker
- Type (delete if not applicable): closed with teflon sheet
- Material, fill volume: Glass, 5 L
- Aeration: No
- Renewal rate of test solution (frequency/flow rate): Every 24 hours
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: charcoal-treated, dechlorinated and aerated tap water in Yokohama, Japan
- Alkalinity: 44 mg/L
- Ca/mg ratio: 17/4.9
- Culture medium different from test medium: Same medium
OTHER TEST CONDITIONS
- Photoperiod: 16 hours in the light, 8 hours in the dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
General condition and mortality were observed everyday.
TEST CONCENTRATIONS
- Range finding study: Perfomed
- Test concentrations: 5 mg/L
- Results used to determine the conditions for the definitive study: Mortality for 96 hours was 0%. - Reference substance (positive control):
- yes
- Remarks:
- copper sulfate pentahydrate (analytical grade)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: No abnormality was detected in all groups.
- Mortality of control: 0% both in blank control group and in vehicle control group
- Other adverse effects control: No adverse effects were detected. - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- LC50: 0.73 mg/L - Sublethal observations / clinical signs:
Table 1. Mortality of Medaka fish
Nominal concentration (mg/L)
Mean measured concentration
(mg/L)
Cumulative mortality
24 Hour
48 Hours
72 Hours
96 Hours
Control
-
0 (0)
0 (0)
0 (0)
0 (0)
Solvent control
-
0 (0)
0 (0)
0 (0)
0 (0)
5
4.93
0 (0)
0 (0)
0 (0)
0 (0)
- Validity criteria fulfilled:
- yes
Reference
Description of key information
No short-term toxicity effects up to the limit of water solubility
Key value for chemical safety assessment
Additional information
One study is available on the toxicity of docosanoic acid (CAS 112-85-6) on fish.
The 96 h test provided by the Ministry of the Environment, Government of Japan (1998) was conducted according to OECD 203 and in accordance with GLP requirements. Medaka (Oryzias latipes) were exposed to docosanoic acid under semi-static conditions in a limit test by using a solvent. Since no mortality was observed the LC50 (96 h) was determined to be > 5.0 mg/L based on nominal concentrations (geometric mean measured concentration: 4.93 mg/L). Thus no effects could be observed within the range of water solubility, which is determined to be 0.016 mg/L.
Based on the results of that study it can be concluded that no acute toxic effects of docosanoic acid on fish are expected up to the limit of water solubility.
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