Registration Dossier
Registration Dossier
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EC number: 601-093-6 | CAS number: 111453-32-8
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Study design
- Estimation method (if used):
- comparison with the behavior of structurally related compound
Results and discussion
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: estimation
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: estimation
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: estimation
Any other information on results incl. tables
Test substance (ZK 39211) |
rac-5-Amino-N-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamic acid |
||
Analogous compound (ZK 39166)
|
rac-N-(2,3-Dihydroxypropyl)-5-nitroisophthalamic acid |
||
Kinetic data for hydrolysis of ZK 39166 at25°C(Report A01762): |
pH |
statement |
half-life,t½ |
|
4 7 9 |
stable* stable* stable* |
> 1 year > 1 year > 1 year |
|
* “Stable” signifies that less than 10 % of the test substance were degraded during 5 days at 50 °C, corresponding to a half-life > 1 year at 25 °C. |
||
Applicant's summary and conclusion
- Executive summary:
On basis of the structural similarity of the test substance ZK 39211 with ZK 39166 (bears a nitro- instead of a amino-group at the benzene ring) hydrolytic stability is expected.
The rate of hydrolysis of ZK 39166 was determined according to EC guideline C.7 at pH 4, 7 and 9.
No hydrolytic degradation occured within 5 days at pH 4, 7 and 9 at 50 +/- 0.1 °C.
According to the EC test guideline, ZK 39166 can therefore be considered hydrolytically stable at pH 4, 7 and 9 (t½ > 1 year at 25 °C).
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