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Diss Factsheets
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EC number: 202-424-3 | CAS number: 95-49-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: description of the method used is too short to be taken into account
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Groups of 4 male and four female rats (150 - 170 g bw) were exposed to atmospheres of o-chlorotoluene (500, 1000 or 40000 ppm (= ca. 2.635, 5.27 or 210.8 mg/l) 6 hours/days, 5 days/week for 3 weeks.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-chlorotoluene
- EC Number:
- 202-424-3
- EC Name:
- 2-chlorotoluene
- Cas Number:
- 95-49-8
- Molecular formula:
- C7H7Cl
- IUPAC Name:
- 1-chloro-2-methylbenzene
- Details on test material:
- purity. no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: young adult Alderly Park strain
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Remarks on MMAD:
- MMAD / GSD: no data
- Duration of treatment / exposure:
- 3 weeks
- Frequency of treatment:
- 6 h/d, 5 d/w
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500, 1000 or 40000 ppm (= ca. 2.635, 5.27 or 210.8 mg/l)
Basis:
- No. of animals per sex per dose:
- 4 males and 4 females
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: no
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 500 ppm
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
500 ppm: no toxic effects
1000 ppm: lethargy, diminished response to noise, traces of blood around the nostrils, low body weight gain;
No changes were found when the blood taken 24 h after the cessation of exposure and the final 24-h urine were analysed
No significant autopsy findings
Histopathological findings: some foamy macrophages observable free in the alveoli
40000 ppm: death of all the exposed animals within 3 minutes
Applicant's summary and conclusion
- Executive summary:
Groups of 4 male and four female rats (150 - 170 g bw) were exposed to atmospheres of o-chlorotoluene (500, 1000 or 40000 ppm (= ca. 2.635, 5.27 or 210.8 mg/l) 6 hours/days, 5 days/week for 3 weeks. Exposure to an atmosphere of 500 ppm (ca. 2.635 mg/l) was without effect.
The NOEL is 500 ppm based on adverse effects observed at 1000 ppm (lethargy, diminished response to noise, traces of blood around the nostrils, low body weight gain).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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