Registration Dossier
Registration Dossier
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EC number: 205-565-9 | CAS number: 142-84-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable report which meets basic scientific principles.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
Materials and methods
- Principles of method if other than guideline:
- See details in remarks on material and methods.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dipropylamine
- EC Number:
- 205-565-9
- EC Name:
- Dipropylamine
- Cas Number:
- 142-84-7
- Molecular formula:
- C6H15N
- IUPAC Name:
- dipropylamine
- Details on test material:
- - Name of test material (as cited in study report): Di-n-propylamine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg
- Diet (e.g. ad libitum): Rockland rabbit diet
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 0.625, 1.25 and 2.5 ml/kg bw (462.5, 925 and 1850 mg/kg bw; conversion in mg/kg bw is based on the density d=0.74 g/cm3)
- No. of animals per sex per dose:
- 4 (males only)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 925 mg/kg bw
- 95% CL:
- 622 - 1 369
- Remarks on result:
- other: conversion in mg/kg bw is based on the density d=0.74 g/cm3
- Mortality:
- 1850 mg/kg bw: 4/4, within 24 h
925 mg/kg bw: 2/4, one animal on day 1 and on day 5 posttreatment
462.5 mg/kg bw: 0/4 - Clinical signs:
- other: no data
- Gross pathology:
- Necrosis of the skin resulted from the covered application. Internal organs of victims appeared pale or opaque. This may have been caused by the corrosive action of the compound on these organs. Only the lung among the 6 that died had hemorrhaged. All others looked normal.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
