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EC number: 203-585-2 | CAS number: 108-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Acute aquatic toxicity data are available in fish following protocols similar to those of guideline studies.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 26.8 mg/L
Additional information
Acute aquatic toxicity data are available in fish following protocols similar to those of guideline studies with the key study selected on the grounds of the study with the lowest reliable LC50.
The 96-hour LC50s of resorcinol in fathead minnows (Pimephales promelas) ranged from 26.8 mg/L (mean measured) to 100 mg/L (nominal) under flow through conditions; under static conditions the 96-hour LC50 ranged from 40 – 60 mg/L. In a flow through test, two individual tests were conducted in which groups of 10 fish were exposed per test concentration (Koppers Company, 1981). In test 1, 10 fish per test group were exposed to mean measured concentrations of 0, 16.2, 25.8, 34, 39.6 and 46.4 mg/L and in test 2 to concentrations of 0, 12.8, 22.8, 32, 40 and 49.8 mg/L. The 96 hr LC50s were = 29.5 (mean measured) and 26.8 (mean measured) mg/L for tests 1 and 2, respectively. These results are consistent with those reported for the purer form of resorcinol. In a study conducted using Resorcin DS technical grade (99% resorcinol), 10 fish per test concentration were exposed to 0, 10, 25, 31.5, 40, 63 and 100 mg/L (nominal) (Hoechst AG, 1981). In the 31.5 to 100 mg/L groups 5 fish died up to 95 hours after addition of the test substance, with the following symptoms: surface swimming, uncoordinated swimming movements, drifting in a lateral position, hyper-reflexivity, reduced frequency of gill action. The fish in the 25 and 10 mg/L groups did not differ in their behavior from those in the control groups. The fish in the 100 mg/L group presented punctuate red flecks on the body surface. Dissection showed no macroscopically visible changes in all test groups. The resulting 96 hr LC50 was 34.7 mg/L (nominal) and the NOEC was 25 mg/L (nominal).
In a 3-day fish embyo test, exposure of zebrafish embryos to the maximum tolerated concentration of resorcinol (200 mg/l) resulted in a significantly decreased concentration of interfollicular T4 hormone content (IT4C) compared to the control (p<0.05). Based on these results, resorcinol was considered to be a thyroid gland disruptor (TGFD). In a further experiment examining the concentration-response of this effects an EC50 of 82 µM was reported, based on decreased IT4C. An LC50 of 5003 µM was also reported, resulting in a Thyroid disrupting Index (TDI; LC50/EC50) of 61.
In a three day fish embryo test, exposure of transgenic zebrafish embryos to a range of resorcinol concentrations resulted in induction of thyroglobulin expression, compared to the control, based on the concentration-dependent increase of the tg;m Cherry fluorescence. Based on these results an EC50 of 3.4 µmol/l was reported along with a BMD20 of 0.663 µmol/l. An LC50 of 5197 µmol/l was also given, resulting in a Thyroid Disrupting Index (TDI: LC50/EC50) of 1529 (Jarque et al 2018).
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