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EC number: 254-875-0 | CAS number: 40292-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Neodecanoyl chlorde is of moderate oral toxicity and is very toxic via inhalation.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 760 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 400 mg/m³ air
Additional information
Sprague-Dawley rats (5/sex/dose) were exposed to NdCl in olive oil via gavage at doses of 1000, 1470, 2150, and 3160 mg/kg-bw (BASF, 1979). The number of deaths was as follows: 1/10 at 1000 mg/kg, 3/10at 1470 mg/kg6/10 at 2150 and10/10 at 3160 mg/kg Animals that died during the study had distension of the GI tract with diarrheic gut contents. No changes were noted at necropsy in animals that survived. The LD50value was 1760 mg/kg-bw in males and females.
In a guideline study (OECD TG 403), Wistar rats (5/sex/concentration) were exposed to NdCl as a vapor for four hours at analytical concentrations of 0, 0.12, 0.27, 0.41, and 0.62 mg/L and observed for 14 days (BASF, 1994). None of the animals exposed to 0.12 or 0.27 mg/L died. All 5 males and 2 females exposed to 0.41 mg/L died within 1 day. All animals exposed to 0.62 mg/L died during exposure. Accelerated and irregular respiration, grasping, snout wiping were noted. Gross pathology of animals that dies revealed hyperemia, oedema, and focal emphysema of the lungs. The 4-hr LC50value for males and females was 0.4 mg/L.
Justification for classification or non-classification
According to the results presented above neodecanoyl chloride is classified as very toxic by inhalation (acute inhal. Cat 1 and R26) and harmful after swallowing ((acute oral cat 4; R22). No classification suggested for acute dermal toxicity as criteria of regulations 67/548/EC and 1272/2008/EC are not met, no data is available, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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