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EC number: 627-132-7 | CAS number: 1227096-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1990-06-05 to 1990-06-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Details on sampling:
- no data
- Vehicle:
- no
- Details on test solutions:
- PREPARATION:
Direct dispersion in water. 1.0 g of test substance was dispersed in water and the volume adjusted to 1 litre.
This stock dispersion was then diluted to give a 10 mg/l stock solution from which serial dilutions were made to give the test series.
The test substance was known to absorb to glassware and so saturation of the absorption sites was achieved by soaking the test vessels overnight prior to the start of the test. The test vessels were emptied, rinsed with the solution to be tested and then refilled with the fresh test solution at 0 hours. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: Laboratory culture originating from a strain supplied by I.R.CH.A., France.
- Selection: Gravid adults were isolated 24 hours prior to initiation of the test. Young daphnids produced overnight were used for testing.
ACCLIMATION
- Acclimation period:
- Acclimation conditions: At 21'C in polypropylene vessels containing two litres of dechlorinated and aged tap water.
Culture conditions ensure that reproduction is by parthenogenesis.
- Type and amount of food: mixture of fry fish food (Liquifry) and a suspension of mixed algae (predominantly Chlorell a spp. ) .
- Feeding frequency: daily. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 50 mg/l as CaC03
- Test temperature:
- 22°C
- pH:
- 7.1 - 7.2
- Dissolved oxygen:
- 7.9 - 8.6 mgO2/L
- Salinity:
- no data
- Nominal and measured concentrations:
- Nominal concentrations: 0.10, 0.18, 0.32, 0.56, 1.0, 1.8, 3.2, 5.6 and 10 mg/l .
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass beakers each containing 200 ml test solution.
- Aeration: none.
- 9 test concentrations plus 1 control each in duplicate.
- 20 animals per concentration.
- Renewal: no
- Loading: 20 ml test solution per organism.
OTHER TEST CONDITIONS
Photoperiod: 16h light : 8h dark.
TEST MEDIUM / WATER PARAMETERS
- Dechlorinated (with sodium thiosulphate) and aged laboratory tap water.
- Total hardness approximately 50 mg/l as CaC03. - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.45 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL = 0.37 - 0.54 mg/L
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.82 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL = 0.64 - 1.1 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- not relevant
- Validity criteria fulfilled:
- not specified
- Executive summary:
Acute toxicity of Amines, bis(hydrogenated tallow alkyl) methyl to Daphnia magna has been investigated through OECD Guideline 202.
Daphnia magna were exposed for 48 hours to a solution of Amines, bis(hydrogenated tallow alkyl) methyl
at different nominal concentrations of 0.10, 0.18, 0.32, 0.56, 1.0, 1.8, 3.2, 5.6 and 10 mg/l.
EC 50 - 48h determined was of 0.45 mg/L and NOEC-48h was of 0.18 mg/L.
Reference
Description of key information
Acute toxicity of Amines, bis(hydrogenated tallow alkyl) methyl to Daphnia magna has been investigated through OECD Guideline 202.
There are two acute daphnia tests available evaluated to be of K2 quality. The study from Handly resulted in the lowest EC50 and this result is as a worst-case used as Key result for this endpoint.
Daphnia magna were exposed for 48 hours to a solution of Amines, bis(hydrogenated tallow alkyl) methyl (old CAS no.: 61788-63-4, New CAS no.: 1227096-04-90) at different nominal concentrations of 0.10, 0.18, 0.32, 0.56, 1.0, 1.8, 3.2, 5.6 and 10 mg/L.
The 48h EC50 determined was of 0.45 mg/L.
The 48h NOEC was of 0.18 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 0.45 mg/L
Additional information
Four studies have been identified concerning impacts of N-C16-18 (even numbered)-alkyl-N-methyl, C16-18 (even numbered)-alkyl-1-amine on mobility/mortality of invertebrates. None of those studies can be considered as Klimish 1 especially due to analytical measurements which were not done. Nevertheless 2 studies have been identified as sufficiently relevant (Klimish 2) for covering the invertebrate toxicity eventhough analytical measurement was not carried out. They were at least done in accordance with OECD 202 guideline and the test substance was well characterized. The worst-case result has been retained for risk assessment and classification purposes.
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