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EC number: 500-082-2 | CAS number: 32492-61-8 1 - 4.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- FROM 16 SEPT 2020 to 12 MARCH 2021
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Details on sampling:
109.06 mg of the test item was dissolved in acetonitrile and adjusted to the mark with acetonitrile in a 10 mL graduated flask to prepare a solution with a concentration of 10906 mg test item per litre. Defined volumes of 0.092 mL of this solution were diluted to 10 mL with buffer solution in screw glass bottles, resulting in a test item concentration of 100.3 mg/L.
A defined volume of 0.7 mL of the samples was diluted to 1 mL with acetonitrile. This results in a nominal concentration in the diluted sample solution of 70.2 mg/L. These samples were analysed by HPLC-UV.- Buffers:
- pH 4
A mixture of 0.1 M potassium citrate (500 mL), 0.1 M sodium hydroxide (80 mL) and water (400 mL) was adjusted to pH 4.00 with 0.1 M sodium hydroxide and filled up to the mark with water in a 1 L graduated flask.
pH 7
A mixture of 0.0667 M potassium dihydrogenphosphate (587 mL) and 0.067 M disodium hydrogenphosphate (400 mL), was adjusted to pH 7.00 with 0.067 M disodium hydrogenphosphate.
pH 9
A mixture of 0.1 M boric acid in 0.1 M potassium chloride (500 mL), 0.1 M sodium hydroxide (100 mL) and water (380 mL) was adjusted to pH 9.00 with 0.1 M sodium hydroxide and filled up to the mark with water in a 1 L graduated flask. - Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 100.3 mg/L
- Duration:
- 1 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 100.3 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 100.3 mg/L
- Duration:
- 1 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 100.3 mg/L
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 100.3 mg/L
- Duration:
- 1 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 100.3 mg/L
- Number of replicates:
- 2 replicates for each timepoint and pH
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- A preliminary test at 50 C and 5 days of incubation was carried out. Since the test item was completely stable under the conditions of the preliminary test, no advance test was carried out.
- Test performance:
- None
- Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- - Formation and decline of each transformation product during test:
- Pathways for transformation:
- Other: - % Recovery:
- ca. 104
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- ca. 5 d
- % Recovery:
- ca. 101
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- ca. 1 d
- % Recovery:
- ca. 105
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- ca. 5 d
- % Recovery:
- ca. 102
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- ca. 1 d
- % Recovery:
- ca. 106
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- ca. 5 d
- % Recovery:
- ca. 101
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- ca. 1 d
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- Preliminary study indicates that the substance is hydrolytically stable and no further study was performed
- Results with reference substance:
- Preliminary study indicates that the substance is hydrolytically stable and no further study was performed
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item is hydrolytically stable in aqueous buffer solutions at a pH 4, 7 and 9 for at least 5 days at 50 oC.
- Executive summary:
The hydrolysis of BPA EO was determined by OECD guideline 111: Hydrolysis as a function of pH. The test was carried out at 50 oC. Samples of the test items were prepared in buffer solutions at pH 4, 7 and 9 and incubated for up to 5 days.
The test item was found to be stable at pH 4, 7 and 9 under the conditions of the test with recovered of 101-102% after day 1 and 104-106% after 5 days. The tentative hydrolysis product bisphenol A was not detected in the samples.
Thus, the test item was hydrolytically stable at pH 4, 7 and 9 during 5 days at 50 C.
Reference
Preliminary study indicates that the substance is hydrolytically stable and no further study was performed
Description of key information
The hydrolysis of BPA EO was determined by OECD guideline 111: Hydrolysis as a function of pH. The test was carried out at 50 oC. Samples of the test items were prepared in buffer solutions at pH 4, 7 and 9 and incubated for up to 5 days.
The test item was found to be stable at pH 4, 7 and 9 under the conditions of the test with recovered of 101-102% after day 1 and 104-106% after 5 days. The tentative hydrolysis product bisphenol A was not detected in the samples.
Thus, the test item was hydrolytically stable at pH 4, 7 and 9 during 5 days at 50 C.
Key value for chemical safety assessment
Additional information
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