Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-377-9 | CAS number: 94-96-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published in a peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexane-1,3-diol
- EC Number:
- 202-377-9
- EC Name:
- 2-ethylhexane-1,3-diol
- Cas Number:
- 94-96-2
- Molecular formula:
- C8H18O2
- IUPAC Name:
- 2-ethylhexane-1,3-diol
- Test material form:
- liquid: viscous
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight: 2-3 kg.
Acclimatized for at least 5 days prior to use.
Randomly assigned to grouprs from pools whose body weights were within the mean +/- 2 SD.
Environmental temperature of 68-80 degrees F.
Relative humidity was 30-60%
Light/dark schedule: 12 h.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Undiluted EHD was applied to the clipped skin of the trunk, and covered using occlusive polyethylene sheeting, adhesive tape and plastic ties. Animals were immobilized for the contact period.
- Duration of exposure:
- 24 h
- Doses:
- Males: 8.0, 11.3 and 16 ml/kg bw, equivalent to 7.5, 10.7 and 15.1 g/kg bw.
Females: 4.0, 8.0, and 16 ml/kg bw, equivalent to 3.8, 7.5, and 15.1 g/kg bw. - No. of animals per sex per dose:
- 5 per sex per dose
- Control animals:
- no
- Details on study design:
- On removal of the occlusive bandage, residual EHD was gently removed from the skin with moist tissue. Animals were examined twice daily for signs of local inflammation and systemic toxicity. Body weights were measured before dosing, and at 7 and at 14 days postdosing. Necropsies were performed on the animals that died, and on survivors sacrificed at the end of the 14-day observation period.
- Statistics:
- LD50 values were calculated by the moving average method.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 10 251 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Reported as 10.88 ml/kg bw, equivalent to 10.25 g/kg bw.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 8 960 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Reported as 9.51 ml/kg bw, equivalent to 8.96 g/kg bw.
- Mortality:
- Five of 5 treated males and 4 of 5 treated females in the high dose group succumbed. Three of 5 males and 2 of 5 females in the intermediate dose succumbed. Deaths occurred between 2 and 5 days
- Clinical signs:
- other: In animals which died, symptoms preceeding death included sluggishness, prostration and unsteady gait. Recovery occurred within 2 days.
- Gross pathology:
- Necropsies of animals which died revealed a few red mottled lungs, a few stomachs having black foci on their surface, and two instances of animals having brown colored liquid in the thoracic cavity. Survivors sacrificed at the end of the observation period did not show any gross pathologic features at necropsy.
- Other findings:
- Local signs of inflammation at the site of the contact with EHD with skin were eythema and edema on the first day, persisting to the time of death at the highest dose. Among the survivors, eythema and edema resolved within 7 days. Desquamation was apparent at 7 days until sacrifice.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Rabbits treated with 2-ethylhexane-1,3-diol under topical occlusive dressings for 24 h showed an LD50 of over 8000 mg/kg bw in males and females. The substance is not classified under Regulation EC No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.