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Diss Factsheets
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EC number: 930-778-5 | CAS number: 1334421-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Consistent with standard methodology at the time although prior to GLP Principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- limited description but close to standard test method
- GLP compliance:
- no
- Remarks:
- prior to GLP Principles
Test material
- Reference substance name:
- Fatty acids, coco, reaction products with 2-[(2-aminoethyl)amino]ethanol
- EC Number:
- 267-058-9
- EC Name:
- Fatty acids, coco, reaction products with 2-[(2-aminoethyl)amino]ethanol
- Cas Number:
- 67784-90-1
- IUPAC Name:
- Fatty acids, coco, reaction products with 2-[(2-aminoethyl)amino]ethanol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: no data (albino rabbits)
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): as is
VEHICLE
no vehicle used - Duration of treatment / exposure:
- The test material was instilled into the right eye, with no further treatment.
- Observation period (in vivo):
- The eyes were examined every 24 hours for 4 days and then again on the 7th day.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing
SCORING SYSTEM: Draize scale
TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein: no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- (Individual Mean for 24-48-72hrs)
- Basis:
- animal: #1, #2, #3
- Time point:
- other: 24-48-72 hr
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: No reversibility observed up to d7
- Remarks on result:
- other: All 3 animals displayed the highest score.
- Irritation parameter:
- iris score
- Remarks:
- (Individual Mean for 24-48-72hrs)
- Basis:
- animal: #1, #2, #3
- Time point:
- other: 24-48-72 hrs
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- other: No reversibility observed up to d7
- Remarks on result:
- other: All 3 animals displayed the highest score
- Irritation parameter:
- conjunctivae score
- Remarks:
- (Individual Mean for 24-48-72hrs)
- Basis:
- animal: #1, #2, #3
- Time point:
- other: 24-48-72 hrs
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- other: No reversibility observed up to d7
- Remarks on result:
- other: All 3 animals displayed the highest score
- Irritation parameter:
- chemosis score
- Remarks:
- (Individual Mean for 24-48-72hrs)
- Basis:
- animal: #1, #2, #3
- Time point:
- other: 24-48-72 hrs
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: No reversibility observed up to d7
- Remarks on result:
- other: All 3 animals displayed the highest score
- Irritation parameter:
- other: discharge
- Basis:
- animal: #1, #2, #3
- Time point:
- other: observation period
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- other: No reversibility observed up to d7
- Remarks on result:
- other: All 3 animals displayed the highest rating
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal: #1, #2, #3
- Time point:
- other: for each time point
- Score:
- 110
- Max. score:
- 110
- Reversibility:
- other: No reversibility observed up to d7
- Remarks on result:
- other: MMTS for each animal
- Irritant / corrosive response data:
- All 3 animals displayed the maximal scores for each parameter and over the whole observation period (7 days). The corneal opacity involved the the whole area.
The observation period stopped on day 7 without any decrease in the intensity of the effects. - Other effects:
- no data.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information (Risk of serious damage to the eyes) Criteria used for interpretation of results: EU
- Conclusions:
- Severe effects to the eyes.
- Executive summary:
A test to determine the potential for eye irritation was conducted using three albino rabbits. Each animal was administered 0.1 ml of the test material to one eye with the other eye serving as a negative control. Observations were recorded at 24, 48, and 72 hours and again at 4 and 7 days.
The test substance induced severe damages to the eyes (maximum scores observed in all the animals for each of the parameters).
The test substance is considered to be an extreme irritant to rabbit eyes under the test conditions.
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