Registration Dossier
Registration Dossier
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EC number: 233-131-9 | CAS number: 10042-76-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Read across from SrCl2 to Sr(NO3)2 is envisaged due to the fact that possible effects occurred could be regarded as strontium ion related effects. Both substances (SrCl2 and Sr(NO3)2) are "very soluble" (above 10 g/L at 20°C) in water. Hence, it could be concluded that read across is possible.
Justification for selection of skin sensitisation endpoint:
reliable GLP guideline study with strontium chloride available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Justification for selection of respiratory sensitisation endpoint:
Based on an industry survey, during long-year industrial practice no cases of hypersensitivity were observed till now by workers exposed exclusively to strontium nitrate. Thus, no classification as respiratory sensitiser according to regulation (EC) 1272/2008 is required
Justification for classification or non-classification
Sensitisation:
The reference Allen (1997) is considered as the key study on skin sensitisation and will be used for classification. The overall sensitisation results are as follows:
The test material, Strontium chloride-6-hydrate extra pure, produced a 0 % (0/10) sensitisation rate and was classified as a non-sensitiser to guinea pig skin. According to the criteria specified by Directive 67/548/EEC and subsequent regulations, the test item is not classified as skin sensitizer. According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is not classified as Category 1.
Respiratory sensitisation:
Based on an industry survey, during long-year industrial practice no cases of hypersensitivity were observed till now by workers exposed exclusively to strontium nitrate. Thus, no classification as respiratory sensitiser according to regulation (EC) 1272/2008 is required.
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