Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 272-805-7 | CAS number: 68912-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 >5000 mg/kg bw (similar to OECD TG 401, limit test)
Acute dermal toxicity: LD50 >5000 mg/kg bw (similar to OECD TG 402, limit test)
Acute inhalation toxicity: LD50: >35000 mg/m3 (calculated using route to route extrapolation from the acute oral toxicity results)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The acute oral toxicity is of sufficient quality and adequate for this dossier.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The information is based on a roughly route to route extrapolation and sufficiently adequate to address the endpoint for hazard, classification and labelling and risk characterisation.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The acute dermal toxicity is of sufficient quality and adequate for this dossier.
Additional information
Acute oral toxicity
The acute oral toxicity of Cyclaprop was determined in an acute oral toxicity study according to methods similar to OECD401 (limit test), in which ten male rats were dosed 5000 mg/kg bw test material. All animals survived, resulting in a LD50 > 5000 mg/kg bw. The most prevalent toxic signs were lethargy, piloerection and chromorhinorrhea. Internal organs of all animals, necropsied on day 14, were normal upon superficial examination.
Acute dermal toxicity
In an acute dermal toxicity test, which was performed according to methods similar to OECD402 (limit test), 10 New Zealand White rabbits were exposed to 5000 mg/kg bw Cyclaprop under gauze patches and secured with adhesive tape. One death occurred, resulting in a LD50 > 5000 mg/kg bw. Most animals were generally healthy throughout the test period. Skin reactions (scored according to Draize) were non-existent to slight (one surviving animal with scaly skin) and body weight changes were within expected limits. All animal were normal upon necropsy, only one animal, dead on day 14, had liver nodules and scaly skin.
Acute inhalation toxicity
Acute inhalation toxicity is not anticipated because when the oral LD50 values are compared with the Saturated Vapour Concentration (SVC) of the substance, the result is that the inhalation LD50 value exceeds the SVC and thus the inhalation LC50 cannot be reached. This is calculated as follows: Cyclaprop has an oral LD50 of >5000 mg/kg bw, which can be converted to an inhalation LD50 using the equation: “Incorporated dose = concentration x respiratory volume x exposure time”: 1 mg/kg bw = 0.0052 mg/l/4h (ECHA guidance on CLP, 2017). In addition, for conservative reasons the inhalation absorption is set at 100% and oral at 50%. For Cyclaprop the LC 50 would be > 13000 mg/m3. Its SVC at ca. 20°C is 57 mg/m3. This SVCvalue can be calculated using vapour pressure and molecular weight (MW 206*VP (Pa) 0.67*1000 / 8.3 (gas constant)*293°K (20°C). In conclusion: with a maximum SVC of 57 mg/m3 the inhalation LC50 of > 13000 cannot be reached. Therefore, an LC50 for inhalation cannot be reached and no classification and labelling is needed for the acute inhalation route.
Justification for classification or non-classification
Cyclaprop does not need to be classified for acute oral, dermal and inhalation toxicity based on the information above and in accordance with EU CLP (EC 1272/2008 and its amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.