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Diss Factsheets
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EC number: 203-813-0 | CAS number: 110-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Piperidine: a new neuromodular or a hypogenic substance?
- Author:
- Giacobini E.
- Year:
- 1 976
- Bibliographic source:
- Adv Biochem Psychopharmacol 15, 17-56 (1976)
- Reference Type:
- secondary source
- Title:
- Volatile amines in brain.
- Author:
- Honegger CG and Honegger R
- Year:
- 1 960
- Bibliographic source:
- Nature, 185, 530-532 (1960), cited in Giacobini 1976: Piperidine. Adv Biochem Psychopharmacol 15, 17-56 (1976)
- Reference Type:
- secondary source
- Title:
- Distribution of piperidine in the brain and its possible significance in behaviour.
- Author:
- Abood LG, Rinaldi F and Eagleton V
- Year:
- 1 961
- Bibliographic source:
- Nature 19, 201-202 (1961) cited in Giacobini 1976: Piperidine. Adv Biochem Psychopharmacol 15, 17-56 (1976)
- Reference Type:
- secondary source
- Title:
- Estimation of picomole quantities of piperidine in tissues.
- Author:
- Seiler N, Schneider NH
- Year:
- 1 974
- Bibliographic source:
- Biomed. Mass. Spectr., 1, 381-385 (1974); cited in Giacobini 1976: Piperidine. Adv Biochem Psychopharmacol 15, 17-56 (1976)
- Reference Type:
- secondary source
- Title:
- Piperidine in the cerebellum of the dog.
- Author:
- Kataoka M, Kasé Y, Miyata, T and Kawahito E
- Year:
- 1 970
- Bibliographic source:
- J. Neurochem., 17, 291-292 (1970) cited in Giacobini 1976: Piperidine. Adv Biochem Psychopharmacol 15, 17-56 (1976)
- Reference Type:
- secondary source
- Title:
- Amine content of normal human cerebrospinal fluid.
- Author:
- Perry TL, Hansen S, Jenkins LC
- Year:
- 1 964
- Bibliographic source:
- J. Neurochem. 11, 49-53 (1964), cited in Giacobini 1976: Piperidine. Adv Biochem Psychopharmacol 15, 17-56 (1976)
Materials and methods
- Type of study / information:
- Summary and critical analysis of the data of piperidine about metabolism, its cellular localization, and its catabolism in the brain as well as elucidation of its possible role in the function of the nervous system, including recent work of the author's laboratory.
- GLP compliance:
- no
Test material
- Reference substance name:
- Piperidine
- EC Number:
- 203-813-0
- EC Name:
- Piperidine
- Cas Number:
- 110-89-4
- Molecular formula:
- C5H11N
- IUPAC Name:
- piperidine
Constituent 1
Results and discussion
Any other information on results incl. tables
Piperidine is found in muscle, liver, heart, kidney, spleen, testes, small intestine, lung of rats at concentrations ranging from 0.115–0.440 nmol/g tissue. Piperidine is also found in the brain of the rat, mouse, cat, pig and rabbit.
The highest endogenous concentrations are found in the brain: In the whole mouse and rat brain the piperidine concentration ranged from 0.016–3.28 nmol/g tissue depending on the extraction and analysis procedures. The concentration in whole human brain was reported as 1.8 nmol/g tissue. The highest concentrations of piperidine in the brain are found in the cerebellum:
3.92–5.18 nmol/g of tissue for the dog, 3.07–3.17 nmol/g of tissue for the mouse, 0.8 nmol/g of tissue for the cat, and 0.047 nmol/g of tissue for the rat. The concentration in other brain regions varied considerably.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.