Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-075-6 | CAS number: 13598-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline study, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Skin irritation patch test, as described in Federal Register 1973, Vol. 38, No. 187, Section 1500: 41.
- Deviations:
- not specified
- Principles of method if other than guideline:
- Occluded application of test material to shaved abraded and intact skin of six rabbits and assessed for primary irritation.
- GLP compliance:
- no
- Remarks:
- Conducted prior to requirement for GLP
Test material
- Reference substance name:
- Ammonium perrhenate
- EC Number:
- 237-075-6
- EC Name:
- Ammonium perrhenate
- Cas Number:
- 13598-65-7
- Molecular formula:
- H4N.O4Re
- IUPAC Name:
- Ammonium oxido(trioxo)rhenium
- Details on test material:
- - Name of test material (as cited in study report): Ammonium perrhenate
- Substance type: white powder
- Physical state: solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: “recognised breeders”
- Age at study initiation: 16-18 weeks
- Weight at study initiation: 2.4 kg (average)
- Diet: ad libitum commercial rabbit diet supplied by Rank Hovis MacDougal
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): “natural lighting conditions”
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Backs of the rabbits were shaved (not “closely clipped” as recommended by the OECD guidelines). One site on each rabbit was abraded immediately before application of the test materials, the other site remained intact.
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
VEHICLE
- Amount(s) applied (volume or weight with unit): “sample was moistened with sterile distilled water” - Duration of treatment / exposure:
- 24 hrs
- Observation period:
- 48 hrs after removal of patch
- Number of animals:
- Six females
- Details on study design:
- TEST SITE
- Area of exposure: each site 2.5 cm2 (one site intact, one site abraded)
- Type of wrap if used: Gauze pad was secured by “Sleek” adhesive tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
SCORING SYSTEM: Oedema and erythema (and eschar) formation were assessed on the non-abraded and abraded skin of six rabbits 24 and 72 hrs after the initial application of the test material (i.e. as soon as the dressing was removed and again 48 hr later). The primary irritation index was then calculated by adding the four values for eryhtema (and eschar) formation to the four for oedema formation, and dividing the total by four. According to the study report, Draize (1959) considers that “compounds producing combined averages (primary irritation indices) of 2 or less are only mildly irritating; whereas those with indices of 2 to 5 are moderate irritants, and those with scores above 6 are considered severe irritants”.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hrs after initial application.
- Score:
- 0.08
- Reversibility:
- other: Reversibility was not assessed as the observation period was only for 48 hrs after removal of the patch (not up to 14 days as recommended in the OECD guidelines).
- Irritant / corrosive response data:
- See Individual rabbit results under Attached background material, below.
- Other effects:
- The systemic toxicity was not reported.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Ammonium perrhenate (0.5 g) produced a primary irritation index of 0.08 following occluded application to the shaved abraded and intact skin of six rabbits, and therefore would be classified at most as only a mild irritant in this test system. This study was not performed to current guidelines.
- Executive summary:
Ammonium perrhenate (0.5 g) was applied (occluded) to the shaved abraded and intact skin of six female rabbits. After 24 hrs, the dressings were removed and the abraded and intact skin sites were quantitatively assessed for erythema (and eschar) formation and oedema formation. Readings were again made 48 hrs later. Slight reddening (“barely perceptible”) was seen in one rabbit, 24 and 72 hours following exposure, only on the abraded skin. No other reactions were observed in any other animals. Overall scores were combined and divided by four to give a primary irritation score or 0.08, which would be deemed to be at most only mildly irritating in this test system. This study suffered from a number of significant deviations when compared with current OECD guidelines, including use of abraded skin, a longer exposure period and failure to wash off any residual test material after removal of the patch, observation period was insufficient to assess reversibility of effects, and skin was only examined on 2 occasions, at 0 and 48 hrs, rather than at 1, 24, 48 and 72 hrs, after removal of the patch. However, certain of these deviations would likely increase the possibility of an irritant reaction and thus ammonium perrhenate would be unlikely to cause significant skin irritation in a study performed to current OECD guidelines.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.