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Diss Factsheets
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EC number: 227-177-9 | CAS number: 5698-98-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Kinetic parameters for acrylic acid oxidation in isolated mouse and rat tissue of liver, kidney and skin were determined. All tissues were able to oxidize acrylic acid to a certain extent, but with considerable variation. The kidney and the liver were the organs showing the highest oxidation rates. Acrylic acid was rapidly absorbed and eliminated after single oral doses. Exhalation of 14CO2 was the major route of elimination, accounting for approximately 80-90% of the administered dose (94% of recovered radioactivity) after either dose level. This process was rapid and nearly complete within 8 h after administration. A somewhat slower rate of 14CO2 exhalation after the latter dose appeared to reflect slower absorption of the bolus dose. Less than 2% of the dose remained in tissues or carcass 72 h after dosing. Urinary excretion accounted for about 3-4% of the dose, with most occurring over the first 24 h. Excretion in faeces accounted for less than 0.2% of the dose. Only trace amounts of exhaled organic volatile compounds other than 14CO2 were detected. The rates of acrylic acid oxidation in tissues from male and female mice were similar. Following an oral dose of [14C]acrylic acid to rats, a rapid elimination was noted. Within 8 hr 35-60% of the dose was eliminated from the animals with most of the elimination occurring as expired carbon dioxide. By 24 hr 50-65% of the dosed radioactivity had been eliminated, and the excretion of radioactivity had virtually ceased. This information can be used for read across to Magnesium acrylate. See justification in the attached read across justification document to the CSR.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.