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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 606-097-1 | CAS number: 186817-80-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- other: expert statement
- Adequacy of study:
- supporting study
- Study period:
- 2009
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: expert statement
Data source
Reference
- Reference Type:
- other: expert statement
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
- Principles of method if other than guideline:
- Expert statement
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhexyl-S-lactate
- IUPAC Name:
- 2-ethylhexyl-S-lactate
Constituent 1
Results and discussion
- Details on results:
- The results presented make clear that lactate esters are rapidly hydrolysed by esterases in a number of mammalian tissues, including nasal olfactory epithelium, liver, skin, intestinal mucosa, and blood.
Chemical hydrolysis is much slower. No data are as yet available on the hydrolysis of lactate esters under the conditions prevailing in the stomach (low pH).
Rapid hydrolysis is not restricted to lactate esters, but has also been observed for a series of other esters, which are used as food flavours. Thus the results obtained with the lactate esters fit within a general pattern.
It may be assumed that upon oral exposure at relatively low dose levels, systemic exposure to lactate esters consists largely, probably entirely of exposure to lactic acid and the alcohol.
In particular, the esterase activity in the intestinal mucosa, the liver and the blood, will prevent any significant exposure to the parent ester when doses are low in comparison to the available esterase activity.
The esterase activities in the skin and in the blood, also point to systemic exposure to lactic acid and alcohol upon dermal exposure.
Taken together, data on the toxicity of lactic acid and the alcohols should play an important role when the human health hazards of lactate esters have to be assessed. Depending on anticipated routes and levels of exposure, they can make toxicity testing with the lactate esters themselves redundant
Applicant's summary and conclusion
- Conclusions:
- Data on the toxicity of lactic acid and the alcohols should play an important role when the human health hazards of lactate esters have to be assessed. Depending on anticipated routes and levels of exposure, they can make toxicity testing with the lactate esters themselves redundant
- Executive summary:
The influence of hydrolysis of the esters on the systemic exposure was investigated by ENVIRON, based on information provided by PURAC and information available in the public domain. The information laid down in the report is meant to serve as a background document when information on the toxicological properties of lactic acid and the alcohols is used to supplement or substitute information on the esters themselves. The results presented make clear that lactate esters are rapidly hydrolysed by esterases in a number of mammalian tissues, including nasal olfactory epithelium, liver, skin, intestinal mucosa, and blood. Chemical hydrolysis is much slower. No data are as yet available on the hydrolysis of lactate esters under the conditions prevailing in the stomach (low pH). Rapid hydrolysis is not restricted to lactate esters, but has also been observed for a series of other esters, which are used as food flavours. Thus the results obtained with the lactate esters fit within a general pattern. It may be assumed that upon oral exposure at relatively low dose levels, systemic exposure to lactate esters consists largely, probably entirely of exposure to lactic acid and the alcohol. In particular, the esterase activity in the intestinal mucosa, the liver and the blood, will prevent any significant exposure to the parent ester when doses are low in comparison to the available esterase activity. The esterase activities in the skin and in the blood, also point to systemic exposure to lactic acid and alcohol upon dermal exposure. Overall, data on the toxicity of lactic acid and the alcohols should play an important role when the human health hazards of lactate esters have to be assessed. Depending on anticipated routes and levels of exposure, they can make toxicity testing with the lactate esters themselves redundant
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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