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EC number: 203-983-6 | CAS number: 112-54-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The test substance was assessed for acute toxicity to aquatic invertebrates according to OECD guideline 202. The test material was not toxic to Daphnia magna at the limit of solubility. To avoid unnecessary chronic testing, the highest measured soluble concentration of 0.42 to 0.53 mg/L was taken into account for derivation of PNECaquatic.
Key value for chemical safety assessment
Additional information
The test substance was assessed for acute toxicity to aquatic invertebrates according to OECD guideline 202. A semi-static test design with test medium renewal at 24 hours in completely filled and sealed vessels was chosen to ensure that the concentration of the test item remained as high as possible over the 48-Hour test period. To avoid the potential photolytic degradation of the test item, the test was carried out in the dark and all test item preparation was performed under laboratory safety lighting and/or shielded from the light.
Pre-study solubility work conducted indicated that it was not possible to obtain a testable solution of the test item using traditional methods of preparation e.g. ultrasonication. A pre-study media preparation trial indicated that the use of a prolonged stir saturated solution method of preparation was inappropriate since it resulted in the presence of an additional peak which was considered to be due to the autoxidation of the test item. The results obtained from a solvent spike method of preparation indicated that a maximum dissolved test item concentration of approximately 0.48 mg/l was obtained indicating this to be the solubility limit of this test item under test conditions. The concentration and stability of the test item in the test preparations was verified by chemical analysis at 0 and 24 hours (fresh media) and at 24 and 48 hours (old media).
No immobilisation or adverse effects were observed at the maximum nominal concentration of 0.48 mg/l (the solubility limit of test item in the test media). Thus the 48-hour EC50 was greater than 0.48 mg/L and the corresponding NOEC was 0.48 mg/L based on nominal concentrations.Chemical analysis of the freshly prepared test media at 0 and 24 hours showed measured test concentrations to range from 0.42 mg/L to 0.53 mg/L (equivalent to 87% to 121% of nominal). A decline in measured test concentration was observed at 24 and 48 hours in the range of 56% to 75% of nominal at 24 hours and less than the limit of quantitation (LOQ) of the analytical method employed, which was determined to be 0.035 mg/l at 48 hours. Based on time-weighted mean measured concentrations, the No Observed Effect Concentration was 0.27mg/L. However, the decline in measured concentrations were a result of unavoidable loss of test substance due to abiotic degradation and therefore cannot be used to derive an EC50 or NOEC.
To avoid unnecessary chronic testing, the initial measured soluble concentrations of 0.42 to 0.53 mg/L were taken into account for derivation of PNECaquatic.
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