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EC number: 700-064-6 | CAS number: 2105830-60-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Esterification product of castor oil and tetrahydromethyl-1,3-isobenzofuranedione
- EC Number:
- 700-064-6
- Cas Number:
- 2105830-60-0
- Molecular formula:
- Not applicable as this is a UVCB substance
- IUPAC Name:
- Esterification product of castor oil and tetrahydromethyl-1,3-isobenzofuranedione
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Remarks on result:
- other: Not toxic at loadings significantly above the solubility limit
Any other information on results incl. tables
Acute Toxicity Study in Daphnia magna with the Substance.
The study procedures described in this report were based on the OECD guideline No. 202, 2004. In addition, the procedures were designed to meet the test methods of the EEC directive 92/69, Part C.2, 1992, the ISO International Standard 6341, 1996 and the OECD series on testing and assessment number 23, 2000.
The batch of the Substance tested was a very viscous amber liquid and not completely soluble in test medium at the loading rate tested. Preparation of the test solution started with a 1: 1 stock in acetone. 260 µl (-200 mg) of this stock was added to 1 litre of ISO medium resulting in a nominal concentration of 100 mg/l. After a 3-day stirring period and a 10-minute stabilisation period, the aqueous mixture (containing test substance particles) was filtered through a membrane filter (0.45 µm). The clear and colourless filtrate was used for testing.
A limit test was performed, exposing twenty daphnids per concentration (four replicates, with five daphnids each) to the filtered solution and to a control. The total test period was 48 hours.
The project did not include sampling for determination of actual exposure concentrations. The study met the acceptability criteria prescribed by the protocol and was considered valid. The Substance did not induce acute immobilisation of Daphnia magna in a filtered solution prepared at a loading rate of 100 mg/l after 48 hours of exposure (NOEC). Hence, the 48h-EC50 was beyond the maximum soluble concentration.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present study the Substance did not induce acute immobilisation of Daphnia magna in a filtered solution prepared at a loading rate of 100 mg/l after 48 hours of exposure (NOEC). Hence, the 48h-EC50 was beyond the maximum soluble concentration.
- Executive summary:
SUMMARY
Acute Toxicity Study in Daphnia magna with the Substance.
The study procedures described in this report were based on the OECD guideline No. 202, 2004. In addition, the procedures were designed to meet the test methods of the EEC directive 92/69, Part C.2, 1992, the ISO International Standard 6341, 1996 and the OECD series on
testing and assessment number 23, 2000. The batch of the Substance tested was a very viscous amber liquid and not completely soluble in test medium at the loading rate tested. Preparation of the test solution started with a 1: 1 stock in acetone. 260 µl (-200 mg) of this stock was added to 1 litre of ISO medium resulting in a nominal concentration of 100 mg/l. After a 3-day stirring period and a 10-minute stabilisation period, the aqueous mixture (containing test substance particles) was filtered through a membrane filter (0.45 µm). The clear and colourless
filtrate was used for testing. A limit test was performed, exposing twenty daphnids per concentration (four replicates, with five daphnids each) to the filtered solution and to a control. The total test period was 48 hours. The project did not include sampling for determination of actual exposure concentrations. The study met the acceptability criteria prescribed by the protocol and was considered valid. the Substance did not induce acute immobilisation of Daphnia magna in a filtered solution prepared at a loading rate of 100 mg/l after 48 hours of exposure (NOEC). Hence, the 48h-EC50 was beyond the maximum soluble concentration.
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