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Diss Factsheets
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EC number: 415-510-2 | CAS number: 145703-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
In rats, LD50 > 2000 mg/kg bw after oral and dermal exposure to test substance.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
As for the oral route, acute toxicity of the substance was tested on rats. The parameters observed at periodic intervals up to day 15 were mortality, clinical signs, body weights and macroscopic findings after necropsy at day 15.
The results are reported: no deaths occurred during the study period; no clinical signs of systemic toxicity were seen, the only sign noted was local alopecia in the right cheek of 3 males, but this was not considered as toxicologically relevant; no relevant changes in body weights were noted; at post mortem examination no significant changes were noted.
Acute toxicity upon dermal exposure was tested in rats. The parameters observed at periodic intervals up to day 15 were: mortality; body weights; clinical signs, focusing on general behaviour, respiration, eye, nose, motility, body posture, motor susceptibility, skin and other possible signs; macroscopic findings after necropsy at day 15.
The results are reported: no deaths occurred during the study period; no clinical signs of systemic toxicity were seen, the only sign noted was red discoloration of the skin in all treated animals (5 males and 5 females) at 2000 mg/kg bw dose; no relevant changes in body weights were noted; no organ abnormalities at post mortem examination.
The inhalation route was not tested due to the physical features of the substance, that suggest a minimal probability of systemic exposure by this route. In particular, the substance has a negligible vapour pressure, thus being unlikely available for inhalation as a vapour. Moreover, it has a mass median diameter between 63 - 250 µm, thus indicating that only a small fraction may be inhaled by nose and mouth; whereas, the respirable fraction of particles, i.e. diameter < 4 µm, is less than 4 %.
According to the CEN document, EN 481 ‘Workplace Atmospheres – size fraction definitions for measurement of airborne particles’ (CEN 1993), particles above 100 µm are not inhalable.
Under the test conditions, during the observation period, the substance did not induce systemic toxicity.
Justification for selection of acute toxicity – oral endpoint
The study is reliable and representative.
Justification for selection of acute toxicity – dermal endpoint
The study is reliable and representative.
Justification for classification or non-classification
The threshold of classification for oral and dermal acute toxicity according to the CLP Regulation (EC 1272/2008) is a LD50 value of 2000 mg/kg bw. By considering both the exposure routes, no deaths occurred up to the highest testes dose of 2000 mg/kg bw. Thus, no classification is required since the LD50 of the substance is above the classification range.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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