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Diss Factsheets
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EC number: 202-879-8 | CAS number: 100-69-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May, 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study for transportation classification. There is limited information on purity of the test material, but this was material meeting the specifications and characteristics of material shipped.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DOT, Federal Register, 49 CFR, Subpart D, 173.136-137
- Deviations:
- no
- Principles of method if other than guideline:
- Test material is applied to the trunks of shaved New Zealand white rabbits under occlusive conditions for 1 hour. The test material was gently wiped off the skin. Test sites were evaluated again at 48 hours and scored for edema, eschar, necrosis.
- GLP compliance:
- no
- Remarks:
- but meeting internal laboratory quality criteria
Test material
- Reference substance name:
- 2-vinylpyridine
- EC Number:
- 202-879-8
- EC Name:
- 2-vinylpyridine
- Cas Number:
- 100-69-6
- Molecular formula:
- C7H7N
- IUPAC Name:
- 2-ethenylpyridine
- Details on test material:
- 2-Vinylpyridine, Lot # 40310AA, a clear amber liquid.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 1 hour
- Observation period:
- 1 hour and 48 hours
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hours
- Reversibility:
- not reversible
- Remarks on result:
- other: All 6 animals displayed skin necrosis at 48 hours.
- Irritant / corrosive response data:
- All 6 animals displayed eschar and irreversible alteration of the tissue evidenced by ulceration and necrosis
- Other effects:
- Skin was discolored purple at the site of test material administration
Any other information on results incl. tables
Positive for corrosion after a 1 hour exposure.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: other: U.S. Department of Transportation
- Conclusions:
- 2 -Vinylpyridine is corrosive to the skin of rabbits after a 1 hour exposure. The U.S. DOT classification is Class 8, Packing Group II. GHS Category 1B.
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