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EC number: 219-775-3 | CAS number: 2528-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
Test material
- Reference substance name:
- Heptanoyl chloride
- EC Number:
- 219-775-3
- EC Name:
- Heptanoyl chloride
- Cas Number:
- 2528-61-2
- Molecular formula:
- C7H13ClO
- IUPAC Name:
- heptanoyl chloride
- Details on test material:
- Name of the test substance used in the study report: n-Heptansaeurechlorid
Purity: 98.6%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The age of the animals at the beginning of the study was 8 - 9 weeks.
The animals were identified individually by color marking on the tail.
The animals were offered KLIBA rat/mouse/hamster laboratory diet 24-343-4 10 mm pellets, Klingentalmühle AG, Kaiseraugst, Switzerland, and drinking water ad libitum during the post-exposure observation period.
The animals were kept in fully air-conditioned rooms in which a temperature in the range of 20-24°C and relative humidity in the range of 30-70% were regulated by means of a central air-conditioning system.
The animals were housed singly in cages type DK III of Becker, without bedding, with a light/dark rhythm of 12 hours.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Duration of exposure:
- 4 h
- Concentrations:
- 0.11, 0.34 and 0.51 mg/l
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
The body weight of the animals was determined just prior to exposure, after 7 days and at the end of the observation period. A check for overt clinical signs of toxicity or mortality as well as a check for feed and drinking water was made twice a day on workdays and once daily on weekends and public holidays. Detailed clinical observations were recorded for each animal separately several times during exposure and at least once on each workday in the observation period.
At the end of the 14-day observation period the surviving animals were sacrificed with CO2 and were subjected to gross-pathological examination like all other animals which had died before. - Statistics:
- The statistical evaluation of the dose-response relationship was carried out using a computer program: Depending on the data of the dose-response
relationship obtained by way of experiment, this program is used to estimate the LC50 or to perform a Probit analysis. Estimation of the LC50 will produce types LC50 greater, LC50 about, or LC50 smaller. If the results are Type LC50 greater or LC50 smaller, an additional binomial test is carried out in order to verify these statements statistically, if necessary.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.39 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 0.3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- ca. 0.51 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- At the end of the study
0.11 mg/l: no mortalities
0.34 mg/l: 4 males and no female
0.51 mg/l: 5 males and 2 females - Clinical signs:
- other: Irregular, accelerated and intermittent respiration, respiratory sounds (only males), nose - discharge - bloody (only females), apathy, squatting posture, lateral position (only males), piloerection, smeared fur
- Body weight:
- Male animals:
0.11 mg/l - start of exposure 238 g, after 14 days 318 g
0.34 mg/l - start of exposure 255 g, after 14 days 302 g
0.51 mg/l - start of exposure 259 g, after 7 days all animals died
Female animals:
0.11 mg/l - start of exposure 196 g, after 14 days 221 g
0.34 mg/l - start of exposure 182 g, after 14 days 197 g
0.51 mg/l - start of exposure 190 g, after 14 days 207 g - Gross pathology:
- Animals that died:
0.34 mg/l - lung: diffuse dark-red discolouration of all lobes.
0.51 mg/l - lung: diffuse dark-red discolouration of all lobes, retracted surface - severe
Surviving animals:
No abnormalities detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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